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Concept of extremes in vascular aging: from early vascular aging to supernormal...

Laurent, Stephane; Boutouyrie, Pierre; Cunha, Pedro Miguel Guimarães Marques; Lacolley, Patrick; Nilsson, Peter M.

[Excerpt] With advancing age, changes in the arterial wall contribute to what has been called vascular aging, and in some prematurely affected subjects even early vascular aging (EVA).1–5 Several years ago,1 we listed various components of EVA, including arteriosclerosis, atherosclerosis, and excess vasoconstriction, with their clinical expression: arterial stiffening and increased central pulse pressure, carot...


Characteristics of healthy vascular ageing in pooled population-based cohort st...

Nilsson, Peter M.; Laurent, Stephane; Cunha, Pedro Miguel Guimarães Marques; Olsen, Michael H.; Rietzschel, Ernst; Franco, Oscar H.; Ryliškytė, Ligita

Arterial ageing is characterized by increasing arterial stiffness as measured by pulse wave velocity (PWV). This process is enhanced in participants with early vascular ageing (EVA), but slowed in participants with healthy vascular ageing (HVA). We aimed to describe characteristics of EVA and HVA in a transcontinental study including 11 cohorts.


Early Vascular Ageing (EVA): Definitions and Clinical Applicability.

Cunha, Pedro Miguel Guimarães Marques; Boutouyrie, Pierre; Nilsson, Peter M.; Laurent, Stéphane

Arterial stiffness has been accumulating evidence as an intermediate cardiovascular endpoint. It has been established as an independent risk marker for cardiovascular disease, and reflects the dissociation between chronologic and biologic age of large arteries-attributing earlier the risk that a normal vascular ageing process had installed to occur several years later. The concept of Early Vascular Ageing (EVA)...


Pulse wave velocity distribution in a cohort study: from arterial stiffness to ...

Cunha, Pedro G.; Cotter, Jorge; Oliveira, Pedro; Vila, Isabel; Boutouyrie, Pierre; Laurent, Stéphane; Nilsson, Peter M.; Scuteri, Angelo; Sousa, Nuno

BACKGROUND: By contrast with other southern European people, north Portuguese population registers an especially high prevalence of hypertension and stroke incidence. We designed a cohort study to identify individuals presenting accelerated and premature arterial aging in the Portuguese population. METHOD: Pulse wave velocity (PWV) was measured in randomly sampled population dwellers aged 18-96 years from north...


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