152 documents found, page 1 of 16
Microcephaly measurement in adults and its association with clinical variables
Costa,Nicole Rezende da; Mancine,Livia; Salvini,Rogerio; Teixeira,Juliana de Melo; Rodriguez,Roberta Diehl; Leite,Renata Elaine ParaizoABSTRACT OBJECTIVE To establish a microcephaly cut-off size in adults using head circumference as an indirect measure of brain size, as well as to explore factors associated with microcephaly via data mining. METHODS In autopsy studies, head circumference was measured with an inelastic tape placed around the skull. Total brain volume was also directly measured. A linear regression was used to determine the asso...
Telemedicine use among neurologists before and during COVID-19 pandemic
Aquino,Emanuelle Roberta da Silva; Domingues,Renan Barros; Mantese,Carlos Eduardo; Fantini,Francisca Goreth Malheiro Moraes; Nitrini,RicardoABSTRACT Background: After the public health emergency due to COVID-19 was declared in Brazil, the federal government temporarily regulated and authorized the use of telemedicine services for patient consultation, monitoring, and diagnosis. For more than a decade, neurologists have recognized the benefits of telemedicine in the acute management of stroke patients. However, as the use of telemedicine was restric...
Active lifestyle enhances protein expression profile in subjects with Lewy body...
Real,Caroline Cristiano; Suemoto,Cláudia Kimie; Binda,Karina Henrique; Grinberg,Lea Tenenholz; Pasqualucci,Carlos Augusto; Jacob Filho,WilsonABSTRACT. Clinical trials of the effects of physical activity have reported improvements in symptoms and quality of life in patients with Parkinson's disease (PD). Additionally, morphological brain changes after exercising were reported in PD animal models. However, these lifestyle-related changes were not evaluated in postmortem brain tissue. Objective: We aimed to evaluate, by immunohistochemistry, astrocytes...
The Figure Memory Test: diagnosis of memory impairment in populations with hete...
Nitrini,Ricardo; Brucki,Sonia Maria Dozzi; Yassuda,Mônica Sanches; Fichman,Helenice Charchat; Caramelli,PauloABSTRACT. Diagnosis of cognitive impairment is usually difficult in low-educated individuals. The Brief Cognitive Screening Battery (BCSB) was designed as a screening tool for the evaluation of cognitive impairment in low-educated individuals, but it may also be used for evaluating individuals with high educational level. Objectives: To perform a narrative review analyzing the origin of the BCSB, to report all ...
Assessment of judgment ability in a Brazilian sample of patients with mild cogn...
Vale-Britto,Patrícia Helena Figueirêdo do; Rabin,Laura; Spindola,Livia; Nitrini,Ricardo; Brucki,Sonia Maria DozziABSTRACT. Judgment is the ability to make sound decisions after consideration of relevant information, possible solutions, likely outcomes, and contextual factors. Loss of judgment is common in patients with mild cognitive impairment (MCI) and dementia. The Test of Practical Judgment (TOP-J) evaluates practical judgment in adults and the elderly, with 15- and 9-item versions that require individuals to listen t...
Subjective sleep parameters in prodromal Alzheimer’s disease: a case-control study
Borges,Conrado R.; Piovezan,Ronaldo D.; Poyares,Dalva R.; Busatto Filho,Geraldo; Studart-Neto,Adalberto; Coutinho,Artur M.; Tufik,SergioObjective: People with Alzheimer’s disease (AD) dementia have impaired sleep. However, the characteristics of sleep in the early stages of AD are not well known, and studies with the aid of biomarkers are lacking. We assessed the subjective sleep characteristics of non-demented older adults and compared their amyloid profiles. Methods: We enrolled 30 participants aged ≥ 60 years, with no dementia or major clini...
Telemedicine in neurology: current evidence
Domingues,Renan Barros; Mantese,Carlos Eduardo; Aquino,Emanuelle da Silva; Fantini,Francisca Goreth Malheiro Moraes; Prado,Gilmar Fernandes doABSTRACT Background: Telemedicine was first introduced in Neurology as a tool to facilitate access to acute stroke treatment. More recently, evidence has emerged of the use of telemedicine in several other areas of Neurology. With the advent of the COVID-19 pandemic and the need for social isolation, Brazilian authorities have expanded the regulation of the use of telemedicine, thus allowing the treatment of ma...
Acute Disseminated Encephalomyelitis in COVID-19: presentation of two cases and...
Lopes,Cesar Castello Branco; Brucki,Sonia Maria Dozzi; Passos Neto,Carlos Eduardo Borges; Corazza,Luiza Alves; Baima,José Pedro SoaresABSTRACT Background: Neurological manifestations of COVID-19 are still incompletely understood. Neurological manifestations may be due to direct viral effect on neurons and glial cells, to an immune-mediated response to the virus, or to a hypercoagulable state and associated endothelial damage, as well as to severe systemic disease with prolonged intensive care unit stay. Objective: To describe two patients wit...
MoCA Test: normative and diagnostic accuracy data for seniors with heterogeneou...
Cesar,Karolina G.; Yassuda,Mônica S.; Porto,Fabio H. G.; Brucki,Sonia M. D.; Nitrini,RicardoABSTRACT The Montreal Cognitive Assessment (MoCA) has been described as a good tool to detect cognitive impairment. The ideal MoCA cutoff score is still under debate. The aim was to provide MoCA norms and accuracy data for seniors with a lower education level, including illiterates. Methods: Data originated from an epidemiological study conducted in the municipality of Tremembe, Brazil. The Brazilian MoCA test ...
Alzheimer's disease and sleep disturbances: a review
Borges,Conrado Regis; Poyares,Dalva; Piovezan,Ronaldo; Nitrini,Ricardo; Brucki,SoniaABSTRACT The association between Alzheimer's disease (AD) and sleep disturbances has received increasing scientific attention in the last decades. However, little is known about the impact of sleep and its disturbances on the development of preclinical AD stages, such as mild cognitive impairment. This review describes the evolution of knowledge about the potential bidirectional relationships between AD and sle...