10 documents found, page 1 of 1
A Collaborative Approach for the Development of a Standardized Set of Patient-C...
Joaquim, Ana; Nobre, Ana Rita; Araújo, Cláudia; Vieira, Guy; Alves, Paula; Carinha, Paulo; Ribeiro, LeonorIntroduction: Head and neck cancers remain a significant health burden worldwide. Standardizing the care provided to these patients through the systematic measurement of established indicators is key to improve their outcomes. The aim of this study was to establish a relevant set of outcome indicators in this condition and identify measurement tools and requirements to do so.Methods: One scientific committee an...
The value of PET/CT scan for treatment response evaluation following concurrent...
Carvalho, Miguel; Nobre, Ana Rita; Branquinho, FranciscoObjectives: To define the utility of PET/CT scan for the response evaluation of patients diagnosed with locoregionally advanced HNSCC and evaluate its prognostic value. Study Design: Retrospective study Material and Methods: Retrospective analysis of the clinical records of patients diagnosed with HNSCC between January/2016 and June/2018 at the IPO of Coimbra, treated with concomitant CRT, who underwent a follo...
Audiometric outcomes following radiosurgery for vestibular schwannoma treatment...
Medeiros, Nuno; Nobre, Ana Rita; Carvalho, Ana Filipa; Portugal, Edite; Branquinho, FranciscoIntroduction: Vestibular Schwannoma (VS) corresponds to 8% of all intracranial lesions. Although many patients present themselves with important hearing loss, its worsening is still a major concern. Material and Methods: Retrospective study involving patients suffering from VS who received RadioSurgery from June 2013 until December 2020. Pure tone and speech audiometry were conducted before and after GKRS. Resu...
Phonological memory in patients with head and neck tumors
Trigueiro, Natália; Pina, Flávia; Nobre, Ana Rita; Serrano, Margarida Maria Fernandes, 1964-Background, Hearing loss is one of the major complications of head and neck tumors. The combination of chemotherapy with cisplatin and radiotherapy, increased survival, becoming the standard of treatment for locally advanced tumors. However, all types of treatment, radiation therapy and chemotherapy with cisplatin, are known for their ototoxic effects. These treatments also impact the memory and brain structure...
Vestibular dysfunctions:comparison between patients with head and neck tumors a...
Nobre, Ana Rita; Silva, Carla Matos, 1975-; Guiomar, Júlia; Martins, TâniaBackground, the use of ototoxic drugs is common in patients with head and neck tumors. Consequently, there may be vestibular dysfunctions that are not always detected, affecting the quality of life. Thus, it is important to evaluate the factors that may lead to vestibular system dysfunction. The objective of this study is to determine if vestibular dysfunction in individuals with head and neck tumors who underw...
SRC inhibition prevents P-cadherin mediated signaling and function in basallike...
Ribeiro, Ana Sofia; Nobre, Ana Rita; Mendes, Nuno; Almeida, João; Vieira, André Filipe; Sousa, Bárbara; Carvalho, Filomena Almeida; Monteiro, JoanaBACKGROUND: Basal-like breast cancer (BLBC) is a poor prognosis subgroup of triple-negative carcinomas that still lack specific target therapies and accurate biomarkers for treatment selection. P-cadherin is frequently overexpressed in these tumors, promoting cell invasion, stem cell activity and tumorigenesis by the activation of Src-Family kinase (SRC) signaling. Therefore, our aim was to evaluate if the trea...
Clinical vs. pathological staging in larynx tumors
Melo, Ana Sofia; Nobre, Ana Rita; Portugal, Edite; Branquinho, Francisco; Guimarães, ArnaldoIntroduction: Larynx cancer represent about 30% of head and neck tumors, and 90% are squamous cell carcinomas. Discrepancies have been reported in clinical and pathological TNM staging in larynx cancer in several studies.Methods: Retrospective analysis of 179 patients undergoing laryngectomy between January 2009 and December 2014 in IPOFG of Coimbra. Results: With regard to the extent of the tumor (T), the rest...
The basal epithelial marker P-cadherin associates with breast cancer cell popul...
Sousa, Bárbara; Ribeiro, Ana Sofia; Nobre, Ana Rita; Lopes, Nair; Martins, Diana; Pinheiro, Céline; Vieira, André Filipe; Albergaria, AndréBACKGROUND: Cancer stem cells are hypoxia-resistant and present a preponderant glycolytic metabolism. These characteristics are also found in basal-like breast carcinomas (BLBC), which show increased expression of cancer stem cell markers.Recently, we demonstrated that P-cadherin, a biomarker of BLBC and a poor prognostic factor in this disease, mediates stem-like properties and resistance to radiation therapy....
P-cadherin functional role is dependent on E-cadherin cellular context: a proof...
Ribeiro, Ana Sofia; Sousa, Bárbara; Carreto, Laura; Mendes, Nuno; Nobre, Ana Rita; Ricardo, Sara; Albergaria, André; Cameselle-Teijeiro, Jorge F.P-cadherin overexpression is associated with worse breast cancer survival, being a poor prognostic marker as well as a putative therapeutic target for the aggressive triple-negative and basal-like carcinomas (TNBCs). Previously, we have shown that P-cadherin promotes breast cancer invasion of cells where membrane E-cadherin was maintained; however, it suppresses invasion in models without endogenous cadherins, ...
Late post-traumatic epistaxis in patient with fibromuscular dysplasia - A case ...
Nobre, Ana Rita; Pinto, Sofia; Sousa, Vítor; Ribeiro, CarlosEpistaxis is a very common problem that, in most cases, is of easy control. When it occurs after head trauma, usually happens due to nasal mucosa lacerations or lesion of anterior ethmoidal or sphenopalatine artery branches. Very excepcionally, the bleeding can be so serious and of so difficult management and control that threatens patient´s life. In these situations it is mandatory to investigate and treat vas...