3 documents found, page 1 of 1
Neuroprotective effects of piperine, an alkaloid from the Piper genus, on the P...
Correia, Alyne Oliveira; Cruz, Abílio Augusto Pimentel; Aquino, Arôdo Tenório Ribeiro de; Diniz, Joanisson Rubens GomesPiperine (PIP), an alkaloid from the Piper genus plants, presents biological properties, including potent anti-inflammatory actions. Since neuroinflammation plays a key role in Parkinson's disease (PD), the objectives were to evaluate the neuroprotective activity of PIP in a model of PD. Male Wistar rats were divided as: sham-operated (SO), untreated 6-OHDA (lesioned in the right striatum) and 6-OHDA lesioned a...
Omega-3 fatty acids : possible ceuroprotective mechanisms in the model of globa...
Nobre, Maria Elizabeth Pereira; Correia, Alyne Oliveira; Mendonça, Francisco Nilson Maciel; Uchoa, Luiz Ricardo AraújoBackground. Omega-3 (3) administration was shown to protect against hypoxic-ischemic injury. The objectives were to study the neuroprotective effects of 3, in a model of global ischemia. Methods. Male Wistar rats were subjected to carotid occlusion (30 min), followed by reperfusion. The groups were SO, untreated ischemic and ischemic treated rats with 3 (5 and 10 mg/kg, 7 days). The SO and untreated ischemic an...
Eicosapentaenoic acid and docosahexaenoic acid exert anti-inflammatory and anti...
Nobre, Maria Elizabeth Pereira; Correia, Alyne Oliveira; Borges, Marília de Brito; Sampaio, Thayga Maria Araújo; Chakraborty, Solon ArcoverdeIn the present study, we evaluated omega-3 polyunsaturated fatty acid (PUFA) (consisting of 20:5n-3 and 22:6n-3) properties on inflammation and nociception. Among the in vivo tests, writhing, formalin, and hot plate tests were conducted in mice, and carrageenan-induced paw edema, peritonitis, and Hargreaves tests were performed in rats. Following the carrageenaninduced edema, immunohistochemistry for tumor necr...