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Effect of co-administration of BRL-37344 and tadalafil on reduction of overacti...
Carvalho, Marcos Fiuza de; Pamplona, Thuliermes Lopes; Barreira, Márcio Alencar; Fechine, Francisco Vagnaldo Jamacuru; Gonzaga-Silva, Lúcio FlávioPurpose: To evaluate the impact of the combination of BRL 37344 and tadalafil (TDF) on the reduction of overactive bladder (OB) symptoms. Methods: Thirty mice were randomized into 5 groups (G) of 6 animals each. L-NAME was used to induce DO. G1: Control; G2: L-NAME; G3: L-NAME + TDF; G4: L-NAME + BRL 37344; G5: L-NAME + TDF + BRL 37344. After 30 days of treatment, the animals were submitted to cystometry to eva...
Date: 2019
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Origin: Oasisbr