21 documents found, page 1 of 3
A percepção dos estudantes do Curso de Microbilogia Básica: a atividade docente...
Duarte, Deborah de Lima; Barroso, Fatima Daiana Dias; Farias, Maria Emília Pessoa; Giffony, Priscylla da Silva; Nobre Júnior, Hélio VitorianoAtualmente, apesar dos avanços da tecnologia e das metodologias de ensino aprendizagem, vêm–se discutindo questões acerca da preocupação com a qualidade do ensino superior, sendo essa uma problemática que alcança não somente a escala nacional, mas atinge contornos mundiais, devido sua complexidade e características próprias. Logo, o objetivo do presente trabalho, foi através da elaboração e aplicação de questio...
Antifungal activity of palmatine against strains of Candida spp. resistant to a...
Campos, Rosana de Sousa; Silva, Cecília Rocha da; Andrade Neto, João Batista de; Sampaio, Letícia Serpa; Nascimento, Francisca Bruna Stefany Aires doThe incidence of fungal infections has increased and it is necessary to seek new antifungals that also act against resistant strains. Palmatine is a protoberberine alkaloid noteworthy for its various pharmacological properties, including antifungal properties. The objective of this study was to evaluate the activity of palmatine against Candida spp. strains resistant to azole in planktonic cells and biofilm, an...
In vitro evaluation of the curcumin against fluconazole-resistant strains of Ca...
Freitas, Daniel Domingues; Silva, Cecília Rocha da; Andrade Neto, João Batista de; Campos, Rosana de Sousa; Sampaio, Letícia SerpaThe isolates of Candida spp. and Cryptococcus neoformans were inhibited by curcumin, with different degrees of inhibition among species, with MICs ranging from 8-64 μg/mL. After exposure of the C. albicans strains to curcumin, it was observed a decrease in the number of viable cells and damage to cell membranes, the mitochondrial function of C. albicans cells appears to be affected after exposure to curcumin. O...
Ibuprofen antifungal activity on both planktonic and biofilm forms of fluconazo...
Sampaio, Letícia S.; Silva, Cecília R. da; Campos, Rosana S.; Nascimento, Francisca Bruna Stefany Aires do; Andrade Neto, João Batista deOver the past few decades, researches have reported an increased incidence of invasive candidiasis and suggested that the majority of infections produced by this pathogen are associated with biofilm growth, which are more resistant to antimicrobial agents than planktonic cells. In addition to these problems, there are few antifungal agents available and it is necessary the development of novel therapeutic strat...
Chemical composition and antifungal In vitro and in silico, antioxidant, and an...
Nascimento, José Eranildo Teles do; Rodrigues, Ana LivyaMoreira; Lisboa, Daniele Silva de; Liberato, Hortência Ribeiro; Falcão, Maria José CajazeirasOuratea fieldingiana (Gardner) Engl is popularly used for wound healing. This study describes the main chemical compounds present in extracts of O. fieldingiana and evaluates their biological potential by investigating antifungal, antioxidant, and anticholinesterase activities.The actionmechanismofmain antifungal compound was investigated bymolecular docking using the enzyme sterol 14- demethylase, CYP51, requi...
Antioxidant and anti-inflammatory activities of Bauhinia ungulata L. (Fabaceae)...
Rodrigues, Raphael de Oliveira; Yaochite, Juliana Navarro Ueda; Braga, Milena Aguiar; Sousa, Amanda Ribeiro de; Sasahara, Greyce LuriObjective: The present study aimed to investigate the antioxidant, immunomodulatory and antimicrobial activities of Bauhinia ungulata L. Method: A flavonoid-rich fraction was obtained from the Bauhinia ungulata L stem, called the ethyl acetate fraction of Bauhinia ungulata (FABU). The total antioxidant capacity of the FABU was determined through the phosphomolibdenium reduction method. For the evaluation of its...
Antidepressants, antimicrobials or both? Gut microbiota dysbiosis in depression...
Macedo, Danielle; Chaves Filho, Adriano José Maia; Sousa, Caren Nádia Soares de; Quevedo, João; Barichello, Tatiana; Nobre Júnior, Hélio VitorianoObjectives The first drug repurposed for the treatment of depression was the tuberculostatic iproniazid. At present, drugs belonging to new classes of antidepressants still have antimicrobial effects. Dysbiosis of gut microbiota was implicated in the development or exacerbation of mental disorders, such as major depressive disorder (MDD). Based on the current interest in the gut-brain axis, the focus of this na...
Registros de acidentes com animais peçonhentos (aranhas, escorpiões e serpernte...
Lacerda, Nomario Pedrosa; Silva, Gleice Rayanne da; Santos Júnior, Aníbal de Freitas; Cacavlcanti, Bruno Coelho; Silva, Cecília Rocha daPoisonings are common occurrences, which annually take to the population the demand for specialized health service, with regard to emergency rooms around the world including Braz il. In 2010 it was registered about 90,000 cases of poisoning by exposure to various agents including accidents with animals, but it is estimated that the actual number is almost double of cases, since many incidents are not reported. ...
Screening of antimicrobial metabolite yeast isolates derived biome Ceará agains...
Andrade Neto, João Batista de; Silva, Cecília R. da; Nascimento, Francisca Bruna Stefany Aires do; Sampaio, Letícia Serpa; Silva, Anderson R. daAntimicrobials benefited the history of medicine by revolutionizing the treatment of infectious diseases. However, its consequent and continuous use has led to the emergence of microorganisms which once were considered safe, but have become feared as potentially lethal pathogens (Bowler et al., 2012). Staphylococcus aureus infections are highlighted for being a major cause of systemic infections, and for being ...
Effects of piperonal nitro derivatives on candida species : antifungal activity...
Andrade Neto, João Batista de; Silva, Cecília Rocha da; Campos, Rosana de Sousa; Nascimento, Francisca Bruna Stefany Aires do; Freitas, Daniel DominguesRecently, there has been a significant increase in invasive fungal infections, the treatment of which is limited to a quite small number of antifungal drugs. Natural products represent an important source of antifungal agents, mainly because of their natural coexistence with fungi present in each biome. Derivatives or semi-synthetic products can be used to optimize the pharmacological profile of natural product...