3 documents found, page 1 of 1
Mitochondrial metabolism drives low-density lipoprotein-induced breast cancer c...
Nobrega-Pereira, Sandrina; Santos, Francisco; Oliveira Santos, Miguel; Serafim, Teresa; Lopes, Ana Patrícia; Coutinho, Diogo; Carvalho, FilipaMost cancer-related deaths are due to metastases. Systemic factors, such as lipid-enriched environments [as low-density lipoprotein (LDL)-cholesterol], favor breast cancer, including triple-negative breast cancer (TNBC) metastasis formation. Mitochondria metabolism impacts TNBC invasive behavior but its involvement in a lipid-enriched setting is undisclosed. Here we show that LDL increases lipid droplets, induc...
New insights into the role of epithelial–mesenchymal transition during aging
Santos, Francisco; Moreira, Cristiana; Nobrega-Pereira, Sandrina; Jesus, Bruno Bernardes DeEpithelial⁻mesenchymal transition (EMT) is a cellular process by which differentiated epithelial cells undergo a phenotypic conversion to a mesenchymal nature. The EMT has been increasingly recognized as an essential process for tissue fibrogenesis during disease and normal aging. Higher levels of EMT proteins in aged tissues support the involvement of EMT as a possible cause and/or consequence of the aging pro...
An antisense transcript mediates MALAT1 response in human breast cancer
Gomes, Carla Pereira; Nobrega-Pereira, Sandrina; Domingues Silva, Ana Beatriz; Rebelo, Kenny; Alves-Vale, Catarina; Marinho, Sérgio; Carvalho, TâniaBackground: Long non-coding RNAs (lncRNAs) represent a substantial portion of the human transcriptome. LncRNAs present a very stringent cell-type/tissue specificity being potential candidates for therapeutical applications during aging and disease. As example, targeting of MALAT1, a highly conserved lncRNA originally identified in metastatic non-small cell lung cancer, has shown promising results in cancer regr...