12 documents found, page 1 of 2

Antimalarial resistance risk in Mozambique detected by a novel quadruplex dropl...

Funding text The authors would like to acknowledge Funda\u00E7\u00E3o para a Ci\u00EAncia e a Tecnologia for funds to GHTM (UID/04413/2020) and LA-REAL (LA/P/0117/2020) and Instituto CAM\u00D5ES (https://www.instituto-camoes.pt/) BOLSAS CAM\u00D5ES, FUNDA\u00C7\u00C3O MILLENNIUM BCP (https://www.fundacaomillenniumbcp.pt/en/), Par\u00F3quia de S\u00E3o Nicolau \u2013 Lisboa (to C.D.S.), R01AI150856 (to J.L.G.), ...

Mapping Antimalarial Drug Resistance in Mozambique

Funding Information: Fatima Nogueira (F.N.) was funded by Fundacao para a Ciencia e a Tecnologia (FCT) grant GHTMUID/04413/2020 and LA-REAL-LA/P/0117/2020. Clemente da Silva (C.d.S.) was funded by Instituto CAMOES (https://www.instituto-camoes.pt/) BOLSAS CAMOES, FUNDACAO MILLENNIUM BCP and Paroquia de Sao Nicolau-Lisboa. Publisher Copyright: © 2024 by the authors.; Malaria continues to be a significant public ...

Anti-malarial resistance in Mozambique

© 2023. The Author(s).; BACKGROUND: Malaria remains one of the most serious public health problems in sub-Saharan Africa and Mozambique is the world's fourth largest contributor, with 4.7% of disease cases and 3.6% of total deaths due to malaria. Its control relies on the fight against the vector and treatment of confirmed cases with anti-malarial drugs. Molecular surveillance is an important tool for monitorin...

Characterization and antiplasmodial activities new Thiazole-Thiosemicarbazone d...

Synthetic Red Blood Cell-Specific Glycolytic Intermediate 2,3-Diphosphoglycerat...

Mechanisms of malaria parasite interaction with its host red blood cell may provide potential targets for new antimalarial approaches. Pyruvate kinase deficiency has been associated with resistance to malaria in both experimental models and population studies. Two of the major pyruvate kinase deficient-cell disorders are the decrease in ATP and the increase in 2,3-biphosphoglycerate (2,3-BPG) concentration. Hig...

Prevalence of pfk13 and pfmdr1 polymorphisms in Bounkiling, Southern Senegal

BACKGROUND: Delayed Plasmodium falciparum parasite clearance has been associated with Single Nucleotide Polymorphisms (SNPs) in the kelch protein propeller domain (coded by pfk13 gene). SNPs in the Plasmodium falciparum multidrug resistance gene 1 (pfmdr1) are associated with multi-drug resistance including the combination artemether-lumefantrine. To our knowledge, this is the first work providing information o...

Drug resistance profile and clonality of Plasmodium falciparum parasites in Cap...

BACKGROUND: Cape Verde is an archipelago located off the West African coast and is in a pre-elimination phase of malaria control. Since 2010, fewer than 20 Plasmodium falciparum malaria cases have been reported annually, except in 2017, when an outbreak in Praia before the rainy season led to 423 autochthonous cases. It is important to understand the genetic diversity of circulating P. falciparum to inform on d...

Artemether-lumefantrine treatment failure of uncomplicated Plasmodium falciparu...

Funding Information: We are grateful to the two patients who participated in the study. The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. This work was supported by Funda??o para a Ci?ncia e Tecnologia (FCT) through GHTM (UID/04413/2020); Medical Research Council UK (Grant no. MR/M01360X/1, M...

Heparin administered to Anopheles in membrane feeding assays blocks Plasmodium ...

Innovative antimalarial strategies are urgently needed given the alarming evolution of resistance to every single drug developed against Plasmodium parasites. The sulfated glycosaminoglycan heparin has been delivered in membrane feeding assays together with Plasmodium berghei-infected blood to Anopheles stephensi mosquitoes. The transition between ookinete and oocyst pathogen stages in the mosquito has been stu...

Development of Nanovectors for the Targeted Delivery in Anopheles Mosquitoes of...