16 documents found, page 1 of 2

Real-world data from the Portuguese Nivolumab Expanded Access Program (EAP) in ...

OBJECTIVE: The main aim of the study was to evaluate the efficacy and safety profile of Nivolumab, an immune-checkpoint-inhibitor antibody, in advanced, previously treated, Non-Small Cell Lung Cancer (NSCLC) patients, in a real world setting. METHODS: We performed a retrospective, multicentre data analysis of patients who were included in the Portuguese Nivolumab Expanded Access Program (EAP). Eligibility crite...

Impact of a Heart Failure Clinic on Morbidity, Mortality and Quality of Life

International consensus on natural orifice specimen extraction surgery (NOSES) ...

In recent years, natural orifice specimen extraction surgery (NOSES) in the treatment of colorectal cancer has attracted widespread attention. The potential benefits of NOSES including reduction in postoperative pain and wound complications, less use of postoperative analgesic, faster recovery of bowel function, shorter length of hospital stay, better cosmetic and psychological effect have been described in col...

Coupling the antimalarial cell penetrating peptide TP10 to classical antimalari...

Recently, we disclosed primaquine cell penetrating peptide conjugates that were more potent than parent primaquine against liver stage Plasmodium parasites and non-toxic to hepatocytes. The same strategy was now applied to the blood-stage antimalarial chloroquine, using a wide set of peptides, including TP10, a cell penetrating peptide with intrinsic antiplasmodial activity. Chloroquine-TP10 conjugates displayi...

Clinical, Laboratorial and Immunological Aspects of Severe Malaria in Children ...

Malaria is a parasitic disease of which Plasmodium falciparum causes the most severe form of the disease. The immune response against Plasmodium spp. is complex and remains unclear. The present report aimed to better understand the humoral immune response in severe malaria and analyse new immunodominant antigen candidates as possible serological marker in severe malaria in children. This study included children...

The influence of metabolic syndrome in the outcomes of colorectal cancer patients

AIMS: Determine the influence of metabolic syndrome and its different components in the outcomes of colorectal cancer surgery at 30days. MATERIALS AND METHODS: Prospective study that included all patients submitted to elective colorectal cancer surgery between August 2015 and August 2016 at Hospital de Braga. Clinical and laboratory parameters evaluated pre-operatively were: central obesity, blood pressure, fas...

Nonlinear controller for bispectral index tracking: Robustness and on-line retu...

In this paper, the performance of a control law designed for the automatic administration of propofol and of remifentanil in order to track a desired level for the bispectral index (BIS), used as a measure of the depth of anesthesia, is analyzed under the presence of model parameters uncertainties. It is theoretically proved and illustrated by simulations that under these circumstances the controller has a very...

Polymorphisms in Plasmodium falciparum K13-Propeller in Angola and Mozambique a...

We report the presence of SNPs in Plasmodium falciparum K13-propeller gene in two African countries, Angola and Mozambique, where malaria is a serious public health problem. Samples were collected before and after ACT introduction as first-line treatment. In each country 50 samples collected before and 50 after ACT introduction were analysed. A total of three different mutations (R471R and R575R in Angola and V...

Deep infiltrating endometriosis of the colon causing cyclic bleeding

Comparison of the Antibacterial Activity of Modified-Cotton with Magainin I and...

Wounds are the ideal setting for the development of micro-organisms, so it is often necessary to apply a dressing to control bacterial colonization. Cotton is commonly used in dressings, as it exhibits important hydrophilic characteristics such as high moisture and fluid retention properties, but it may provide a sustainable media for the development of micro-organisms. In this way, the development of new strat...