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Avaliação de Fontes Deinformação : Redes sociais e Desinfodemia
Santos, Alice; Nogueira, Gonçalo; Rodrigues, Liliana; Melo, SantiagoIn our days, the access to information by knowledge-hungry users often takes precedence over its quality. Source evaluation is the key to ensuring a reliable informational foundation, free from misinformation. Social media plays a central role in information dissemination due to its ability to reach a massive audience in real-time; however, the risk of misinformation is high. Fake news has become a scourge of t...
Warfarin–Supplement Interactions: A Systematic Review
Alves, Pedro; Carreira, Bruno; Nogueira, Gonçalo; Sousa, Mariana; Cruz, Agotinho; Cruz, AgostinhoFood supplements, which are concentrated forms of nutrients, play a crucial role in maintaining a balanced diet by providing essential missing nutrients. However, their impact on drug interactions cannot be overlooked. One such drug is warfarin, which is an anticoagulant with a complex interplay involving various medications, foods, and supplements. Given the significant increase in the use of dietary supplemen...
The effect of dosage on the protective efficacy of whole-sporozoite formulation...
Moita, Diana; Rôla, Catarina; Nunes-Cabaço, Helena; Nogueira, Gonçalo; Maia, Teresa G.; Othman, Ahmad Syibli; Franke-Fayard, Blandine; Janse, Chris J.Immunization with Plasmodium sporozoites, either attenuated or administered under the cover of an antimalarial drug, can induce strong protection against malaria in pre-clinical murine models, as well as in human trials. Previous studies have suggested that whole-sporozoite (WSpz) formulations based on parasites with longer liver stage development induce higher protection, but a comparative analysis of four dif...
Pre-erythrocytic activity of M5717 in monotherapy and combination in preclinica...
Fontinha, Diana; Arez, Francisca; Gal, Isabella Ramella; Nogueira, Gonçalo; Moita, Diana; Baeurle, Tobias Hyun Ho; Brito, Catarina; Spangenberg, ThomasCombination therapies have emerged to mitigate Plasmodium drug resistance, which has hampered the fight against malaria. M5717 is a potent multistage antiplasmodial drug under clinical development, which inhibits parasite protein synthesis. The combination of M5717 with pyronaridine, an inhibitor of hemozoin formation, displays potent activity against blood stage Plasmodium infection. However, the impact of thi...
Nonsense-mediated RNA decay and its bipolar function in cancer
Nogueira, Gonçalo; Fernandes, Rafael; García-Moreno, Juan F; Romão, LuísaNonsense-mediated decay (NMD) was first described as a quality-control mechanism that targets and rapidly degrades aberrant mRNAs carrying premature termination codons (PTCs). However, it was found that NMD also degrades a significant number of normal transcripts, thus arising as a mechanism of gene expression regulation. Based on these important functions, NMD regulates several biological processes and is invo...
Nonsense-Mediated mRNA decay in development, stress and cancer
Fernandes, Rafael; Nogueira, Gonçalo; da Costa, Paulo J.; Pinto, Francisco; Romão, LuísaNonsense-mediated mRNA decay (NMD) is a well characterized eukaryotic mRNA degradation pathway, responsible for the identification and degradation of transcripts harboring translation termination codons in premature contexts. Transcriptome-wide studies revealed that NMD is not only an mRNA surveillance pathway as initially thought, but is also a post-transcriptional regulatory mechanism of gene expression, as i...
NMD-associated proteins predicted by an integrative network approach
Nogueira, Gonçalo; Pinto, Francisco; Romão, LuísaThe mechanism of nonsense-mediated decay (NMD) selectively degrades mRNAs carrying a premature translation-termination codon and regulates the abundance of a large number of physiological mRNAs that encode full-length proteins. Although this complex process has been extensively studied along the years, the interactions and connectivity among NMD players is not completely understood. Additionally, some NMD mecha...
Multi-Network approach to predict new proteins involved in NMD
Nogueira, Gonçalo; Pinto, Francisco; Romão, LuísaThe mechanism of nonsense-mediated decay (NMD) selectively degrades mRNAs carrying a premature translation-termination codon and regulates the abundance of a large number of physiological mRNAs that encode full-length proteins. Although this complex process has been extensively studied along the years, the interactions and connectivity among NMD players is not completely understood. Additionally, some NMD mecha...
Integrative network approach to predict new NMD-associated proteins
Nogueira, Gonçalo; Romão, Luísa; Pinto, FranciscoIn our study, we apply such approach to predict new players involved in nonsense-mediated mRNA decay (NMD), a regulatory pathway of mRNA translation that recognizes and selectively degrades specific mRNAs. NMD is a complex process that relies on the involvement of numerous players, however the interactions and connectivity among these components is only partly elucidated.
Genetics of personalized medicine: cancer and rare diseases
Siefers Alves, Inês; Condinho, Manuel; Custódio, Sónia; Pereira, Bruna; Fernandes, Rafael; Gonçalves, Vânia; da Costa, Paulo J.; Lacerda, RafaelaThe 21st annual meeting of the Portuguese Society of Human Genetics (SPGH), organized by Luísa Romão, Ana Sousa and Rosário Pinto Leite, was held in Caparica, Portugal, from the 16th to the 18th of November 2017. Having entered an era in which personalized medicine is emerging as a paradigm for disease diagnosis, treatment and prevention, the program of this meeting intended to include lectures by leading natio...