5 documents found, page 1 of 1
Adulticidal activity of dillapiol and semi-synthetic derivatives of dillapiol a...
Pinto, Ana Cristina da Silva; Nogueira, Karla Lagos; Chaves, Francisco Célio Maia; Silva, Luiz Vilmar Souza da; Tadei, Wanderli Pedro
Stability and antioxidant activity of semi-synthetic derivatives of 4-nerolidyl...
Lima, Emerson Silva; Pinto, Ana Cristina da Silva; Nogueira, Karla Lagos; Silva, Luiz Francisco Rocha de; Almeida, Patrícia Danielle Oliveira de4-nerolidylcatechol (4-NC) is an unstable natural product that exhibits important antioxidant, anti-inflammatory and other properties. It is readily obtainable on a multi-gram scale through straightforward solvent extraction of the roots of cultivated Piper peltatum or P. umbellatum, followed by column chromatography on the resulting extract. Semi-synthetic derivatives of 4-NC with one or two substituent groups...
In vivo antimalarial activity and mechanisms of action of 4-nerolidylcatechol d...
Silva, Luiz Francisco Rocha e; Nogueira, Karla Lagos; Pinto, Ana Cristina da Silva; Katzin, Alejandro Miguel; Sussmann, Rodrigo Antonio Ceschini4-Nerolidylcatechol (1) is an abundant antiplasmodial metabolite that is isolated from Piper peltatum roots. O-Acylation or O-alkylation of compound 1 provides derivatives exhibiting improved stability and significant in vitro antiplasmodial activity. The aim of this work was to study the in vitro inhibition of hemozoin formation, inhibition of isoprenoid biosynthesis in Plasmodium falciparum cultures, and in v...
In vitro inhibition of Plasmodium falciparum by substances isolated from Amazon...
Andrade Neto, Valter Ferreira de; Pohlit, Adrian Martin; Pinto, Ana Cristina da Silva; Silva, Ellen Cristina Costa; Nogueira, Karla LagosIn the present study, a quassinoid, neosergeolide, isolated from the roots and stems of Picrolemma sprucei (Simaroubaceae), the indole alkaloids ellipticine and aspidocarpine, isolated from the bark of Aspidosperma vargasii and A. desmanthum (Apocynaceae), respectively, and 4-nerolidylcatechol, isolated from the roots of Pothomorphe peltata (Piperaceae), all presented significant in vitro inhibition (more activ...
S??ntese e avalia????o da atividade antimal??rica in vitro e in vivo, citotoxic...
Nogueira, Karla LagosSubmitted by Divis??o de Documenta????o/BC Biblioteca Central (ddbc@ufam.edu.br) on 2017-05-23T20:00:00Z No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Disserta????o - Karla L. Nogueira.pdf: 2581121 bytes, checksum: 51f4a19124d973da05a54ea9d7bc1132 (MD5); Approved for entry into archive by Divis??o de Documenta????o/BC Biblioteca Central (ddbc@ufam.edu.br) on 2017-05...