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The involvement of mast cells in the irinotecan-induced enteric neurons loss an...
Nogueira, Ludmila T.; Costa, Deiziane V. S.; Gomes, Antoniella Souza; Martins, Conceição S.; Silva, Angeline M. H. P.; Coelho-Aguiar, Juliana M.Background The irinotecan (CPT-11) causes intestinal mucositis and diarrhea that may be related to changes in the enteric nervous system (ENS). In inflammatory condition, mast cells release a variety of pro-inflammatory mediators that can interact with the ENS cells. It has not been explored whether CPT-11 is able to alter the enteric glial and neuronal cell, and the role of mast cells in this effect. Therefore...
Date: 2017
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Origin: Oasisbr