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Efficacy of exercise on balance, fear of falling, and risk of falls in patients...
Lima,Renata Aparecida de Oliveira; Piemonte,Gabriela Andrade; Nogueira,Célia Regina; Nunes-Nogueira,Vania dos SantosABSTRACT Diabetic peripheral neuropathy (DPN) is the most common complication of diabetes mellitus. Our objective was to evaluate the efficacy of exercise interventions in DPN patients from randomized controlled trials. The primary outcomes were the risk of falls, fear of falling, balance and quality of life. Two reviewers independently selected studies from Embase, Medline, LILACS, CENTRAL, and PEDro. They ass...
Graves’ ophthalmopathy: low-dose dexamethasone reduces retinoic acid receptor-a...
Cury,Sarah Santiloni; Oliveira,Miriane; Síbio,Maria Teresa; Clara,Sueli; Luvizotto,Renata De Azevedo Melo; Conde,Sandro; Jorge,Edson NacibABSTRACT Objective: Graves’ ophthalmopathy (GO) is an autoimmune disease that leads to ocular proptosis caused by fat accumulation and inflammation, and the main treatment is corticosteroid therapy. Retinoid acid receptor-alpha (RARα) seems to be associated with inflammation and adipocyte differentiation. This study aimed to assess the effect of glucocorticoid treatment on orbital fibroblasts of GO patient trea...
Gene expression of estrogen receptor-alpha in orbital fibroblasts in Graves’ op...
Cury,Sarah Santiloni; Oliveira,Miriane; Síbio,Maria Teresa; Clara,Sueli; Luvizotto,Renata De Azevedo Melo; Conde,Sandro; Jorge,Edson NacibGraves’ ophthalmopathy (GO) is one of the most severe clinical manifestations of Graves’ disease (GD), and its treatment might involve high-dose glucocorticoid therapy. The higher incidence of GO among females, and the reported association between polymorphisms of estrogen receptor (ER) and GD susceptibility have led us to question the role of estrogen and its receptor in GO pathogenesis. We, thus, assessed est...
Influência de prolongados períodos de obesidade sobre a expressão gênica miocár...
Lima-Leopoldo,Ana Paula; Leopoldo,André Soares; Silva,Danielle Cristina Tomaz; Nascimento,André Ferreira do; Campos,Dijon Henrique Salomé deFUNDAMENTO: Vários autores mostraram que a deterioração da função cardíaca associa-se com o grau e a duração da obesidade. Os padrões de expressão gênica após longos períodos de obesidade precisam ser estabelecidos. OBJETIVO: Este estudo testou a hipótese de que a exposição prolongada à obesidade leva à redução nos níveis de RNAm de proteínas envolvidas na homeostase do Ca2+ miocárdico. Além disso, este estudo ...
Autoimmune thyroid disease as a risk factor for angioedema in patients with chr...
Missaka,Ruy Felippe Brito Gonçalves; Penatti,Henrique Costa; Silvares,Maria Regina Cavariani; Nogueira,Célia ReginaCONTEXT AND OBJECTIVE: An association between chronic idiopathic urticaria (CIU) and autoimmune thyroid disease (ATD) has been reported. However, there have not been any reports on whether ATD raises the risk of angioedema, which is a more severe clinical presentation of CIU. Thus, the aim of the present study was to evaluate whether the risk of angioedema is increased in patients with CIU and ATD. DESIGN AND S...
Clinical and laboratory evaluation of hyperlipemic and hypothyroid patients
Castro,Ana Valéria Barros de; Bononi,Alexandra Procópio; Aragon,Flávio; Padovani,Carlos Roberto; Nogueira,Célia Regina; Mazeto,Gláucia M. F. da SilvaOBJECTIVE: To determine the frequency of hypothyroidism in a sample of hyperlipemic patients and evaluate clinical and laboratory factors indicative of thyropathy among them. METHODS: Fifty-one hyperlipemic patients, grouped according to an earlier or recent diagnosis of their thyroid function into euthyroid and hypothyroid, were evaluated with clinical and laboratory examinations of blood levels of free T4 and...