3 documents found, page 1 of 1
Revealing a novel Otubain-Like Enzyme from Leishmania infantum with deubiquitin...
Azevedo, Clênia dos Santos; Guido, Bruna Cândido; Pereira, Jhonata L.; Nolasco, Diego O.; Corrêa, Rafael; Magalhães, Kelly Grace; Motta, Flávia NaderDeubiquitinating enzymes (DUBs) play an important role in regulating a variety of eukaryotic processes. In this context, exploring the role of deubiquitination in Leishmania infantum could be a promising alternative to search new therapeutic targets for leishmaniasis. Here we present the first characterization of a DUB from L. infantum, otubain (OtuLi), and its localization within parasite. The recombinant OtuL...
Structural and functional evaluation of the palindromic alanine-rich antimicrob...
Migliolo, Ludovico; Felício, Mário Romão; Cardoso, Marlon H.; Silva, Osmar N.; Xavier, Mary-Ann E.; Nolasco, Diego O.; Oliveira, Adeliana Silva deRecently, several peptides have been studied regarding the defence process against pathogenic microorganisms, which are able to act against different targets, with the purpose of developing novel bioactive compounds. The present work focuses on the structural and functional evaluation of the palindromic antimicrobial peptide Pa-MAP2, designed based on the peptide Pa-MAP from Pleuronectes americanus. For a bette...
A polyalanine peptide derived from polar fish with anti-infectious activities
Cardoso, Marlon H.; Ribeiro, Suzana M.; Nolasco, Diego O.; Fuente-Núñez, César de la; Felício, Mário Romão; Abreu, Sónia Gonçalves; Matos, Carolina O.Due to the growing concern about antibiotic-resistant microbial infections, increasing support has been given to new drug discovery programs. A promising alternative to counter bacterial infections includes the antimicrobial peptides (AMPs), which have emerged as model molecules for rational design strategies. Here we focused on the study of Pa-MAP 1.9, a rationally designed AMP derived from the polar fish Pleu...