7 documents found, page 1 of 1
Reconciling Strategy, Maturity, and Performance Measurement in Industry 4.0
Nolasco, Pedro; Barata, João; Rupino da Cunha, Paulo; Coelho, MiguelMaturity models are essential tools to evaluate Industry 4.0 readiness. However, they have limitations in supporting organizational strategies over time and are insufficient to create company-specific Industry 4.0 roadmaps. This paper presents a research project to steer Industry 4.0 transformation in a leading paper pulp company listed on the Euronext Lisbon stock exchange. The contribution to the body of know...
PVA-Based Hydrogels Loaded with Diclofenac for Cartilage Replacement
Branco, Ana C.; Oliveira, Andreia S.; Monteiro, Inês; Nolasco, Pedro; Silva, Diana C.; Figueiredo-Pina, Célio; Colaço, Rogério; Serro, Ana P.Polyvinyl alcohol (PVA) hydrogels have been widely studied for cartilage replacement due to their biocompatibility, chemical stability, and ability to be modified such that they approximate natural tissue behavior. Additionally, they may also be used with advantages as local drug delivery systems. However, their properties are not yet the most adequate for such applications. This work aimed to develop new PVA-b...
PVA-based hydrogels loaded with diclofenac for cartilage replacement
Branco, Ana C.; Oliveira, Andreia S.; Monteiro, Inês; Nolasco, Pedro; Silva, Diana C.; Figueiredo-Pina, Célio G.; Colaço, Rogério; Serro, Ana P.Polyvinyl alcohol (PVA) hydrogels have been widely studied for cartilage replacement due to their biocompatibility, chemical stability, and ability to be modified such that they approximate natural tissue behavior. Additionally, they may also be used with advantages as local drug delivery systems. However, their properties are not yet the most adequate for such applications. This work aimed to develop new PVA-b...
Chemically crosslinked PVA hydrogels for cartilage substitution
Patacho, Inês; Oliveira, Andreia S.; Nolasco, Pedro; Colaço, Rogério; Serro, Ana P.
Development of polycarbonate urethane-based materials with controlled diclofena...
Oliveira, Andreia S.; Ferreira, Inês; Branco, Ana C.; Silva, João C.; Costa, Carolina; Nolasco, Pedro; Marques, Ana C.; Silva, Diana; Colaço, Rogérioydrogels are very promising human cartilage replacement materials since they are able to mimic its structure and properties. Besides, they can be used as platforms for drug delivery to reduce inflammatory postsurgical reactions. Polycarbonate urethane (PCU) has been used in orthopedic applications due to its long-term biocompatibility and bio-durability. In this work, PCU-based hydrogels with the ability to rel...
Tough and low friction polyvinyl alcohol hydrogels loaded with anti-inflammator...
Oliveira, Andreia Sofia; Schweizer, Sara; Nolasco, Pedro; Barahona, Isabel; Saraiva, Jorge; Colaço, Rogério; Serro, Ana PaulaThe development of new materials that mimic cartilage and its function is an unmet need that will allow replacing the damaged parts of the joints, instead of the whole joint. Polyvinyl alcohol (PVA) hydrogels have raised special interest for this application due to their biocompatibility, high swelling capacity and chemical stability. In this work, the effect of post-processing treatments (annealing, high hydro...
Mineralization of Sialoliths Investigated by Ex Vivo and In Vivo X-ray Computed...
Nolasco, Pedro; Coelho, Paulo V.; Coelho, Carla; Angelo, David F.; Dias, J. R.; Alves, Nuno M.; Maurício, António; Pereira, Manuel F.C.The fraction of organic matter present affects the fragmentation behavior of sialoliths; thus, pretherapeutic information on the degree of mineralization is relevant for a correct selection of lithotripsy procedures. This work proposes a methodology for in vivo characterization of salivary calculi in the pretherapeutic context. Sialoliths were characterized in detail by X-ray computed microtomography (μCT) in c...