Encontrados 36 documentos, a visualizar página 1 de 4
The Impact of Donor Risk Index, Recipients’ and Operative Characteristics on Po...
Cardoso,Filipe S.; Bagulho,Luis; Coelho,João S.; Lamelas,Jorge; Mateus,Élia; Mendes,Milena; Glória,Helena; Ribeiro,Vasco; Mega,Raquel; Pena,AnaAbstract Background and Aims: The donor risk index (DRI) quantifies donor-related characteristics potentially associated with increased risk of early graft failure. We aimed to assess the impact of the DRI, recipient and perioperative factors on post liver transplant (LT) outcomes. Methods: This was a single-center retrospective cohort study including all adult (≥18 years) patients who underwent LT from 01/2019...
The burden of coronary heart disease in simultaneous pancreas-kidney transplant...
Marques,Joana; Pereira,Luísa; Messias,Ana; Fonseca,Nuno; Cotovio,Patrícia; Ferreira,Aníbal; Nolasco,FernandoAbstract Introduction: Type 1 diabetes mellitus is associated with an increased risk of coronary artery disease, which is frequently asymptomatic. This risk increases significantly in those with nephropathy. In selected patients, simultaneous pancreas-kidney transplantation is the renal and pancreatic replacement therapy of choice, as it increases longevity and stabilizes diabetic complications. Despite essenti...
The use of hemodialysis in hypercalcemic crisis secondary to primary hyperparat...
Marouço,Catarina Nazário; Caeiro,Fernando; Costa,Bernardo Marques da; Navarro,David; Magriço,Rita; Nolasco,FernandoABSTRACT Severe hypercalcemia can be either acute or decompensate from a chronic state to a medical emergency, the hypercalcemic crisis. The presence of symptoms such as altered mental status or potentially fatal ECG abnormalities demand an expeditious decrease in serum calcium levels. Standard medical therapy consists of vigorous volume replacement, calcitonin and, depending on the etiology, bisphosphonates, c...
The Kidney Genetics Clinic: delivering precision medicine for kidney patients
Calado,Joaquim; Barata,Rui; Lucas,Rita; Francisco,Telma; Gonçalves,Rui; Ribeiro,Nuno Carrilho; Nolasco,FernandoABSTRACT Molecular genetic testing in human traits has traditionally relied on affiliated academic facilities, been focused on specific phenotypes and supported by research funding. We report the experience of the Kidney Genetics Clinic (“consulta de Doenças Renais Hereditárias”) for the past 5 years, a period during which we have outsourced genetic testing. We evaluated the impact of molecular testing in patie...
Acute kidney injury associated with COVID-19 infection: a case report
Duarte,Tiago; Caeiro,Fernando; Góis,Mário; Matos,António; Viana,Helena; Vieira,César; Paulos,Jorge; Paixão,Paulo; Matos,Bruno; Germano,NunoABSTRACT SARS-Cov2 infection is a highly transmissible disease associated with serious pulmonary disease. Renal involvement is frequent and associated with poor prognosis; however, mechanisms of kidney injury are not well established. We present a SARS-Cov2 patient with severe acute kidney injury. Kidney biopsy findings revealed a pattern of acute tubular necrosis with isometric vacuolization of the proximal tu...
From membranoproliferative glomerulonephritis to a final diagnosis: Hypocomplem...
Marques,Joana; Pereira,Tiago; Carvalho,Dulce; Góis,Mário; Sousa,Helena; Ribeiro,Francisco; Nolasco,FernandoABSTRACT Membranoproliferative glomerulonephritis describes a glomerular-injury pattern common to a heterogeneous group of diseases. Evaluation based on clinical and laboratory presentation and immunofluorescence staining on kidney biopsy allows identification of underlying pathophysiological processes and may facilitate proper diagnosis and treatment. Hypocomplementemic urticarial vasculitis syndrome is a rare...
Neutropenic enterocolitis (typhlitis) in a kidney transplant patient: A case re...
Alves,Rita Valério; Falcão,Luís; Soares,Elsa; Mendes,Milena; Cotovio,Patrícia; Caeiro,Fernando; Aires,Inês; Silva,Cecília; Remédio,FranciscoTyphlitis is a clinical entity rare in adults, reported in immunosuppressed patients. It is a life-threatening condition that occurs in neutropenic patients due to compromised integrity of the bowel wall and its exact pathogenesis is not completely understood. We report a 35-year-old man with a post deceased donor renal and pancreas transplantation status who presented fever and febrile neutropenia. Three days ...
Antibody mediated rejection. Evidence based medicine. What is the current evide...
Menezes,Maria do Mar; Aires,Inês; Nolasco,FernandoAntibody mediated rejection (ABMR) is a major cause of kidney graft loss. The ideal treatment remains unknown, is not standardized and there is little evidence to support the use of any specific therapy. This paper aims to reflect on the current state of this challenging diagnosis, either active or chronic active ABMR, and its treatment options. The current treatments encompass plasma exchange, steroids, intrav...
Simultaneous pancreas-kidney transplantation after liver transplantation: first...
Soares,Elsa; Alves,Rita Valério; Cotovio,Patrícia; Caeiro,Fernando; Aires,Inês; Bigotte,Miguel; Silva,Cecília; Pena,Ana; Bicho,Luís; Martins,AméricoSimultaneous kidney pancreas transplantation, if feasible, is the treatment of choice for the management of end-stage renal disease in patients with type 1 diabetes. This intervention can offer glycemic control and might also stabilize or even reverse some of the metabolic complications of diabetes. Chronic kidney disease has become a critical problem in orthotopic liver transplantation due to multiple risk fac...
Kidney dysfunction in renal amyloidosis: does the complement system play a part...
Ferreira,Ana Carina; Carvalho,Fernanda; Santos,Ana Rita; Nolasco,FernandoIntroduction and aims: The complement system may play a part in the pathogenesis of amyloid disorders. The primary aim of the study was to analyse the relationship between transthyretin renal amyloidosis (ATTR) and the complement system. The secondary aim was to find potential clinical and morphologic features in ATTR amyloidosis associated with complement activation. Methods: We performed a retrospective cohor...