21 documents found, page 1 of 3
Trace elements in portuguese children: urinary levels and exposure predictors
Correia-Sá, Luísa; Fernandes, Virgínia C.; Maia, Maria Luz; Pinto, Edgar; Norberto, Sónia; Almeida, Agostinho; Santos, Cristina; Delerue-Matos, CristinaExposure to environmental chemicals during developmental stages can result in several adverse outcomes. In this study, the exposure of Portuguese children to Cu, Co, I, Mo, Mn, Ni, As, Sb, Cd, Pb, Sn and Tl was evaluated through the analysis of first morning urine through ICP-MS. Furthermore, we attempted to determine possible exposure predictors. The study sample consisted of 54% girls and 46% boys, with a med...
Association between elevated iodine intake and IQ among school children in Port...
Carvalho, Irene P.; Peixoto, Bruno; Caldas, José Carlos; Costa, Ana; Silva, Sofia; Moreira, Bárbara; Almeida, Agostinho; Moreira-Rosário, AndréThe goal of this work was to examine whether elevated iodine intake was associated with adverse effects on IQ among school-age children in Portugal. In a representative sample of children from the north of the country, IQ percentiles by age (assessed with Raven’s Colored Progressive Matrices) were dichotomized to <50 (“below-average” IQs) and ≥50. Morning urine iodine concentrations, corrected for creatinine, w...
Association between Elevated Iodine Intake and IQ among School Children in Port...
Carvalho, Irene P.; Peixoto, Bruno; Caldas, José Carlos; Costa, Ana; Silva, Sofia; Moreira, Bárbara; Almeida, Agostinho; Moreira-Rosário, AndréThe goal of this work was to examine whether elevated iodine intake was associated with adverse effects on IQ among school-age children in Portugal. In a representative sample of children from the north of the country, IQ percentiles by age (assessed with Raven’s Colored Progressive Matrices) were dichotomized to <50 (“below-average” IQs) and ≥50. Morning urine iodine concentrations, corrected for creatinine, w...
Daily intake of wheat germ-enriched bread may promote a healthy gut bacterial m...
Moreira-Rosário, André; Marques, Cláudia; Pinheiro, Helder; Norberto, Sónia; Sintra, Diana; Teixeira, J. A.; Calhau, Conceição; Azevedo, Luís FilipeWheat bran fibre has a beneficial effect on gastrointestinal function, but evidence for wheat germ is scarce. Accordingly, we evaluated the effects of daily intake of wheat germ on gastrointestinal discomfort and gut microbiota by adding wheat germ to refined (white) wheat bread, the most consumed bread type. We hypothesised that an improvement in the composition of refined bread could beneficially affect intes...
Micro-QuEChERS extraction coupled to GC–MS for a fast determination of Bispheno...
Correia-Sá, Luísa; Norberto, Sónia; Delerue-Matos, Cristina; Calhau, Conceição; Domingues, Valentina F.Bisphenol A (BPA) is considered an endocrine disruptor and public concern over BPA exposure has been raised. Several studies have assessed human exposure to this plasticizer, confirming its ubiquitous presence and highlighting children as a public of special concern. A simple, efficient, cheap and green analytical procedure is reported within this paper. This paper reports, for the first time, the development o...
Phthalates and type 1 diabetes: is there any link?
Castro-Correia, Cíntia; Correia-Sá, Luísa; Norberto, Sónia; Delerue-Matos, Cristina; Domingues, Valentina; Costa-Santos, Cristina; Fontoura, ManuelPhthalates are a group of chemical compounds used as plasticizers in the manufacture of plastic materials. They can be present in many commonly used products. There seems to be a relationship between exposure to phthalates and the occurrence of metabolic dysfunctions, such as a decrease in glucose tolerance, oxidative stress, loss of beta cells, and a decrease in insulin synthesis. As beta cells play a key role...
Obesity or diet? Levels and determinants of phthalate body burden – A case stud...
Correia-Sá, Luísa; Kasper-Sonnenberg, Monika; Pälmke, Claudia; Schütze, André; Norberto, Sónia; Calhau, Conceição; Domingues, Valentina F.In this study we analyzed one of the most comprehensive sets of 21 urinary phthalate metabolites representing exposure to 11 parent phthalates (DEP, DMP, DiBP, DnBP, BBzP, DEHP, DiNP, DiDP, DCHP, DnPeP, DnOP) in first morning urine samples of 112 Portuguese children (4-18 years) sampled in 2014/15. The study population consisted of two groups: group 1 with normal weight/underweight children (N = 43) following t...
Exposure assessment to bisphenol A (BPA) in Portuguese children by human biomon...
Correia-Sá, Luísa; Kasper-Sonnenberg, Monika; Schütze, André; Pälmke, Claudia; Norberto, Sónia; Calhau, Conceição; Domingues, Valentina; Koch, Holger M.Exposure to bisphenol A (BPA) is known to be widespread and available data suggests that BPA can act as an endocrine disruptor. Diet is generally regarded as the dominant BPA exposure source, namely through leaching to food from packaging materials. The aim of this study was to evaluate the exposure of 110 Portuguese children (4-18 years old), divided in two groups: the regular diet group (n = 43) comprised hea...
Exposure of Portuguese children to the novel non-phthalate plasticizer di-(iso-...
Correia-Sá, Luísa; Schütze, André; Norberto, Sónia; Calhau, Conceição; Domingues, Valentina; Koch, Holger M.Di-(iso-nonyl)-cyclohexane-1,2-dicarboxylate (DINCH) is used as substitute for high molecular weight phthalate plasticizers such as di-(2-ethylhexyl) phthalate (DEHP) and di-(iso-nonyl) phthalate (DINP). Due to a rapid substitution process we have to assume omnipresent and increasing DINCH exposures. The aim of this study was to evaluate DINCH exposure in 112 children (4-18years old) from Portugal, divided in t...
Effects of environmental pollutants on MCF-7 Cells: A metabolic approach
Norberto, Sónia; Conceicao Calhau; Pestana, Diogo; Faria, AnaSeveral environmental pollutants (EPs) have been associated with biological and molecular processes leading to adverse human health effects, including different types of cancer. Nevertheless, the effects exerted on tumor glucose metabolism are unclear. To evaluate the effects on cellular and molecular mechanisms, namely glucose metabolism, MCF-7 cells were exposed to EPs during short- and long-term exposures. T...