26 documents found, page 1 of 3

The impact on productivity costs of reducing unemployment in patients with adva...

This study aimed to characterize the employment status and work-related conditions of patients with advanced breast cancer (ABC) in Portugal and quantify the productivity costs of premature abandonment of the work market while evaluating strategies to promote employment. The analysis was based on a cumulative incidence model for estimation of ABC prevalence and on a cross-sectional study characterizing the empl...

Modelling Physical Fatigue Through Physiological Monitoring Within High-Risk Pr...

Physical fatigue is not only a tiredness condition but can also be a symptom of various diseases or a precursor of workplace accidents and incidents. High-risk professions like firefighters and military personnel are more frequently exposed to it and its consequences. To contribute to current research efforts towards physical fatigue quantification approaches for these professionals, the current work aimed to t...

Estado de Hidratação de profissionais de Saúde

The Porto European Cancer Research Summit 2021

Key stakeholders from the cancer research continuum met in May 2021 at the European Cancer Research Summit in Porto to discuss priorities and specific action points required for the successful implementation of the European Cancer Mission and Europe's Beating Cancer Plan (EBCP). Speakers presented a unified view about the need to establish high-quality, networked infrastructures to decrease cancer incidence, in...

Low-FODMAP Diet and Its Role in Irritable Bowel Syndrome (IBS) Management

<jats:title>Abstract</jats:title><jats:sec id="S0029665120000956_sec_a1" sec-type="intro"><jats:title>Introduction</jats:title><jats:p>Irritable Bowel Syndrome (IBS) is a functional and multifactorial gastrointestinal disorder characterized by pain, abdominal distention and motility changes, currently diagnosed based on the Rome IV criteria. The efficacy of classic pharmacological, psychological and dietary tre...

A Case of Bortezomib-Associated Thrombotic Microangiopathy in a Multiple Myelom...

Bortezomib is a first-generation proteasome inhibitor used in the treatment of multiple myeloma. We present a case of a 70-year-old woman with multiple myeloma, who presented thrombotic microangiopathy with multi-organ involvement thrombotic microangiopathy (ocular, cardiac, and renal) after bortezomib initiation. A kidney biopsy confirmed the diagnosis of thrombotic microangiopathy. A temporal relation between...

Hyperuricemia in Chronic Kidney Disease: a Role Yet To Be Explained

The role of uric acid as an independent risk factor for chronic kidney disease development and progression is still a matter of discussion. Several observational studies showed a positive association between hyperuricemia and the progression of kidney dysfunction, but others did not, which probably derived from different biases and studies insufficiencies. Moreover, the results from studies on patients in hemod...

Not the Usual Suspect

A nonribosomal peptide synthase gene driving virulence in Mycobacterium tubercu...

Nonribosomal peptide synthases produce short peptides in a manner that is distinct from classical mRNA-dependent ribosome-mediated translation. The Mycobacterium tuberculosis genome harbors a nonribosomal peptide synthase gene, nrp, which is part of a gene cluster proposed to be involved in the biosynthesis of isonitrile lipopeptides. Orthologous clusters are found in other slow-growing pathogenic mycobacteria ...

Biosimilars: a position paper of the European Society for Medical Oncology, wit...

systems. If suitably developed clinically, manufactured to the correct standards and used appropriately, they can positively impact on the financial sustainability of healthcare systems. A critical consideration regarding the introduction of biosimilars into the clinic centres on the required information concerning all the respective procedures. This position paper aims to describe the issues revolving around b...