53 documents found, page 1 of 6
Exploring bio-based alternatives to cyclopentasiloxane: paving the way to promi...
Castro, Mariana; Roque, Catarina; Loureiro, Ana Isabel Sá; Guimarães, Diana Isabel Pereira; Silva, C.; Ribeiro, Artur; Cavaco-Paulo, ArturIn recent years, significant efforts have been made to identify suitable alternatives for silicones commonly used in daily cosmetic products. However, green alternatives have faced challenges in replicating the unique properties of silicone-based formulations, particularly cyclopentasiloxane, which continues to be widely used.This study explores the potential of six biosynthesized esters (heptyl heptanoate, hep...
NADES-in-Oil Emulsions Enriched with Essential Oils for Cosmetic Application
Freitas, David; Rocha, Diana; Santos, Joana; Noro, Jennifer Martins; Tavares, Tânia D.; Teixeira, Marta O.; Araújo, Daniela; Castro, Joana Isabel ReisThis research aims to explore the potential benefits of natural deep eutectic solvents (NADES) in formulating translucent NADES-in-oil emulsions (TEs) containing essential oils (EOs) for cosmetic applications. The TEs investigated in this study are based on previous formulations, consisting of 50 wt.% egg phosphatidylcholine (EPC), 20 wt.% ethanol, 20 wt.% olive oil (OlO), thyme oil (TO), or oregano oil (OrO), ...
Biosynthesis of new amphiphilic esters with emulsifying properties for long-ter...
Roque, Catarina; Castro, Mariana; Castro, Tarsila Gabriel; Ribeiro, Artur; Silva, C.; Cavaco-Paulo, Artur; Noro, Jennifer MartinsIn this work, several amphiphilic compounds were successfully synthesized via lipase-catalysis: 2-(2-ethoxyethoxy)ethyloctanoate, 2-(2-ethoxyethoxy)ethyldecanoate, 2-(2-ethoxyethoxy)ethylpalmitate, (2-(2-ethoxyethoxy)ethyloleate) and (2-(2-ethoxyethoxy)ethyllinoleate). The reactions were carried out using octanoic acid, decanoic acid, palmitic acid, oleic acid, and linoleic acid, as the aliphatic compounds, and...
Laccase-catalyzed polymerized natural bioactives for enhanced mushroom tyrosina...
Costa, Diana; Rocha, Diana; Santos, Joana; Noro, Jennifer Martins; Ribeiro, Artur; Silva, CarlaSkin hyperpigmentation disorders, such as melasma, are linked to excessive melanin production, primarily regulated by the enzyme tyrosinase (TYR). While current inhibitors like kojic acid (KA) are effective, they often cause adverse side effects, driving the search for safer andnatural alternatives. This study evaluated the TYR inhibitory potential of bioactive-rich extracts from acorn, cocoa, cork, and eucalyp...
Prevascularized spongy-like hydrogels maintain their angiogenic potential after...
Ribeiro, Sara Cristina Freitas; Moreira, H.; da Silva, Lucília Pereira; Noro, Jennifer Martins; Sampaio-Marques, B.; Ludovico, Paula; Jarnalo, M.The chronic shortage of organs and tissues for transplantation represents a dramatic burden on healthcare systems worldwide. Tissue engineering offers a potential solution to address these shortages, but several challenges remain, with prevascularization being a critical factor for in vivo survival and integration of tissue engineering products. Concurrently, a different challenge hindering the clinical impleme...
Solvent-free synthesis of hydrophobic and amphiphilic esters using a chemically...
Roque, Catarina S.; Castro, Mariana de; Castro, Tarsila G.; Silva, C.; Cavaco-Paulo, Artur; Noro, Jennifer MartinsUsing lipases to catalyze the synthesis of the most differentiated type of compounds remains one of the major challenges among scientists. Seeking more economic and advantageous catalysts is a current goal of green chemistry. In this work, we demonstrate the potential of a chemically modified form of lipase from Thermomyces lanuginosus (cmLTL) for the synthesis of both hydrophobic (heptyl heptanoate, heptyl oct...
Novel keratin-based particles encapsulating essential oils: a step towards deve...
Fernandes, Mariana P.; Matamá, Maria Teresa Gonçalves Macedo; Noro, Jennifer Martins; Costa, André F.; Silva, Carla; Fernandes-Ferreira, ManuelEssential oils (EOs) are playing a pivotal role in pest control within biologic farming due to their botanical origin and potential as biocontrol agents. However, their use is still limited by challenges like high volatility, rapid oxidation, and susceptibility to degradation in field conditions. Additionally, EOs might present some health risks to humans through inhalation or direct contact during application....
Developing translucent emulsions using sustainable NADES-based extracts
Freitas, David; Rocha, Diana; Santos, Joana; Noro, Jennifer Martins; Tavares, Tânia D.; Teixeira, Marta O.; Araújo, Daniela; Castro, JoanaIn this work, we explored natural deep eutectic solvents (NADES) for developing translucent NADES-in-oil emulsions (TEs) for cosmetic applications. NADES, composed of lactic acid and glycerol (1:1 and 1:4 ratios), were selected for their natural origin, non-toxicity, and compatibility with living organisms. These green solvents facilitated the extraction of bioactive compounds from Lavandula angustifolia, Corym...
Physicochemical properties of new silicone alternatives unraveled by experiment...
Ferreira, Tiago; Rocha, Diana; Freitas, David Silva; Noro, Jennifer Martins; Castro, Mariana de; Loureiro, Ana Isabel Sá; Silva, CarlaThe cosmetic industry has recognized an increasing demand for environmentally sustainable solutions due to the classification of certain commonly used components as bioaccumulative and hazardous. The European Union has implemented restrictions on the utilization of some components, including silicones, which limit their concentration. The present investigation intends to find new solutions for cosmetic formulat...
Hydroxyapatite/alginate/gellan gum inks with osteoconduction and osteogenic pot...
Bastos, Ana Raquel Fernandes; da Silva, Lucília Pereira; Maia, F. Raquel; Franco, Albina Ribeiro; Noro, Jennifer Martins; Silva, CarlaThere is a growing demand for engineered bone tissues custom-designed to match the patient-specific defect size and in vitro models for studying bone diseases and/or drug screening. Herein, we propose a bioprinted bone tissue construct using SaOs-2 cells within alginate/gellan gum/hydroxyapatite inks. Different ink formulations were developed with varying hydroxyapatite content and then evaluated for viscoelast...