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Thermo-mechanical performance of nanostructured electrospun composites produced...
Teixeira, Marta Albertina; Fertuzinhos, Aureliano Costa; Freitas, David Silva; Silva, C.; Ferreira, Diana P.; Felgueiras, Helena PradoThe purpose of this research was to analyze the morphology, thermal and mechanical properties of poly(vinyl alcohol) (PVA)-based electrospun mats reinforced with cellulose acetate (CA) or cellulose nanocrystalline (CNC) for potential applications in wound dressings. Bead-free and water-stable electrospun nanofibers made of blends of PVA and CA or CNC were successfully produced and crosslinked with glutaraldehyd...
Antibacterial and hemostatic capacities of cellulose nanocrystalline-reinforced...
Teixeira, Marta Albertina; Antunes, Joana Isabel Costa; Seabra, Catarina Leal; Fertuzinhos, Aureliano Costa; Tohidi, Shafagh Dinparast; Reis, SaletteInfection is a major issue in chronic wound care. Different dressings have been developed to prevent microbial propagation, but an effective, all-in-one (cytocompatible, antimicrobial and promoter of healing) solution is still to be uncovered. In this research, polyvinyl alcohol (PVA) nanofibrous mats reinforced with cellulose nanocrystal (CNC), at 10 and 20% v/v ratios, were produced by electrospinning, crossl...
Tiger 17 and pexiganan as antimicrobial and hemostatic boosters of cellulose ac...
Teixeira, Marta Albertina; Antunes, Joana Isabel Costa; Seabra, Catarina Leal; Tohidi, Shafagh Dinparast; Reis, Salette; Amorim, M. T. Pessoa deIn this research, we propose to engineer a nanostructured mat that can simultaneously kill bacteria and promote an environment conducive to healing for prospective wound care. Polyvinyl alcohol (PVA) and cellulose acetate (CA) were combined at different polymer ratios (100/0, 90/10, 80/20% v/v), electrospun and crosslinked with glutaraldehyde vapor. Crosslinked fibers increased in diameter (from 194 to 278 nm),...
Poly(vinyl alcohol)-based nanofibrous electrospun scaffolds for tissue engineer...
Teixeira, Marta Albertina; Amorim, M. T. Pessoa de; Felgueiras, Helena PradoTissue engineering (TE) holds an enormous potential to develop functional scaffolds resembling the structural organization of native tissues, to improve or replace biological functions and prevent organ transplantation. Amongst the many scaffolding techniques, electrospinning has gained widespread interest because of its outstanding features that enable the production of non-woven fibrous structures with a dime...
Antimicrobial action and clotting time of thin, hydrated poly(Vinyl Alcohol)/ce...
Felgueiras, Helena Prado; Teixeira, Marta Albertina; Tavares, Tânia Daniela Eugénio; Homem, Natália Cândido; Zille, Andrea; Amorim, M. T. Pessoa dePoly(vinyl alcohol)/cellulose acetate (PVA/CA) films were prepared via a new method that combines principles from solvent casting and phase inversion. To guarantee some degree of flexibility, films were produced with a higher percentage of PVA compared to CA, from 90/10 to 50/50. The antimicrobial peptide (AMP) LL37 was then anchored using dopamine as a binding agent. Films were characterized in terms of functi...
Potentialities of LL37 for Wound Healing Applications: Study of Its Activity in...
Felgueiras, Helena Prado; Teixeira, Marta Albertina; Amorim, M. T. Pessoa deWound healing is a dynamic and complex process that results from the interaction between cytokines, growth factors, blood components and the extracellular matrix. Conventional dressings made of natural or synthetic materials have only the ability to manage the wound and protect it from repeated trauma. With the advancement of technology, wound dressings have evolved and are now capable of intervening in the hea...
New method to produce poly(vinyl alcohol)/cellulose acetate films with improved...
Felgueiras, Helena Prado; Teixeira, Marta Albertina; Tavares, Tânia Daniela Eugénio; Amorim, M. T. Pessoa deNew alternatives to the conventional wound dressings are being engineered. Here, we propose the processing of two biodegradable polymers, poly(vinyl alcohol) (PVA) and cellulose acetate (CA), in the form of films via a new method that combines principles of solvent casting and phase-inversion. Highly flexible and mechanically resistant films were obtained. PVA/CA films were then treated with the antibiotic vanc...
Thermo‐mechanical behaviour of human nasal cartilage
Fertuzinhos, Aureliano Costa; Teixeira, Marta Albertina; Ferreira, Miguel Gonçalves; Fernandes, Rui; Correia, Rossana; Malheiro, Ana Rita; Flores, PauloThe aim of this study was to undergo a comprehensive analysis of the thermo‐mechanical properties of nasal cartilages for the future design of a composite polymeric material to be used in human nose reconstruction surgery. A thermal and dynamic mechanical analysis (DMA) in tension and compression modes within the ranges 1 to 20 Hz and 30 °C to 250 °C was performed on human nasal cartilage. Differential scanning...
Cellulose acetate in wound dressings formulations: potentialities and electrosp...
Teixeira, Marta Albertina; Amorim, M. T. Pessoa de; Felgueiras, Helena PradoAny open wound is a potential site for microorganisms’ invasion since their presence around us is inevitable. Skin wound healing relies on a series of complex physiochemical processes that remain a big challenge for healthcare professionals, particularly when the wounds are colonized by bacteria. Wound dressings play a major role in wound healing as they manage the wounded site, controlling the moisture balance...
On the mechanical characterization of bovine bone tissue under compressive loading
Fertuzinhos, Aureliano Costa; Teixeira, Marta Albertina; Isabel Dias; Flores, Paulo; Zille, Andrea; Dourado, N.This study reveals a pioneer characterization of bovine trabecular bone tissue under dynamic compressive loading in the range of 20-140 oC, within physiological loading frequencies (1-20 Hz). The presented results demonstrate that the viscous behaviour in compression mode up to 140 oC is regulated by the collagen viscoelastic properties, showing three frequency-independent main peaks in tanδ and loss modulus at...