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Neuro-Behçet: A Clinical Exercise

Oliveira, MA; Pereira da Silva, JA; Nour, D; Macário, MC; Malcata, AB; Porto, A; Siva, A; Yazici, H

Behçet disease is a recurrent systemic vasculitis of unknown etiology, that involves vessels of nearly all sizes and types. Because of this, disease manifestations can occur at many sites throughout the body. Central nervous system (CNS) involvement may be parenchymal or nonparenchymal and has a global prevalence that ranges from 3% to 10%. Main signs of CNS involvement are pyramidal and those resulting from br...


Artropatia dos joelhos como manifestação inicial de neoplasia pulmonar

Inês, L; Santos, MJ; Silva, C; Braña, A; Nour, D; Reis, P; Malcata, AB; Porto, A

Apresentamos o caso de uma doente de 46 anos que recorreu ao serviço de urgência por dor e tumefacção dos joelhos com 3 meses de evolução. Na subsequente observação em Reumatologia identificou--se a presença de baqueteamento digital nas mãos e pés (com cerca de 1 ano de evolução) e edema dos membros inferiores. As radiografias dos ossos longos demonstraram a presença de periostose. A investigação de causas de o...



Differential male and female adrenal cortical steroid hormone and cortisol resp...

Silva, C; Inês, L; Nour, D; Straub, RH; Pereira da Silva, JA

Evidence from experimental animal studies show that sex hormones influence the glucocorticoid response to a variety of inflammatory and noninflammatory stimuli. In this study we assessed gender differences in the response of ACTH and cortisol in normal young male and female humans following intravenous infusion of human IL-6 in various dosages. Males presented a significantly stronger ACTH production in respons...


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