5 documents found, page 1 of 1
Novel monoclonal antibody L2A5 specifically targeting sialyl-Tn and short glyca...
Loureiro, L; Sousa, D; Ferreira, D; Chai, W; Lima, L; Pereira, C; Lopes, C; Correia, V; Silva, L; Li, C; Santos, L; Ferreira, JA; Barbas, A; Palma, AIncomplete O-glycosylation is a feature associated with malignancy resulting in the expression of truncated glycans such as the sialyl-Tn (STn) antigen. Despite all the progress in the development of potential anti-cancer antibodies, their application is frequently hindered by low specificities and cross-reactivity. In this study, a novel anti-STn monoclonal antibody named L2A5 was developed by hybridoma techno...
Besnoitia besnoiti protein disulfide isomerase (BbPDI): molecular characterizat...
Marcelino, E; Martins, TM; Morais, JB; Nolasco, S; Cortes, H; Hemphill, A; Leitão, A; Novo, CExp Parasitol. 2011 Oct;129(2):164-74. Epub 2011 Jul 3. Besnoitia besnoiti protein disulfide isomerase (BbPDI): molecular characterization, expression and in silico modelling. Marcelino E, Martins TM, Morais JB, Nolasco S, Cortes H, Hemphill A, Leitão A, Novo C. Source Instituto de Investigação Cientifica Tropical, CIISA, Faculdade de Medicina Veterinária, Universidade Técnica de Lisboa, Av. da Universidade Téc...
The Role of the Humoral Immune Response in the Molecular Evolution of the Envel...
Borrego, P; Marcelino, JM; Rocha, C; Doroana, M; Antunes, F; Maltez, F; Gomes, P; Novo, C; Barroso, H; Taveira, NBACKGROUND: This study was designed to investigate, for the first time, the short-term molecular evolution of the HIV-2 C2, V3 and C3 envelope regions and its association with the immune response. Clonal sequences of the env C2V3C3 region were obtained from a cohort of eighteen HIV-2 chronically infected patients followed prospectively during 2-4 years. Genetic diversity, divergence, positive selection and glyc...
Use of a new dual-antigen enzyme-linked Immunosorbent assay to detect and chara...
Marcelino, JM; Barroso, H; Goncalves, F; Silva, SM; Novo, C; Gomes, P; Camacho, R; Taveira, NA dual-antigen enzyme-linked immunosorbent assay specific for human immunodeficiency virus type 2 (HIV-2) envelope proteins, ELISA-HIV2, was developed with two new recombinant polypeptides, rpC2-C3 and rgp36, derived from the HIV-2 envelope. The diagnosti
Production and characterization of a mouse monoclonal antibody against the Gag ...
Marcelino, JM; Novo, C; Pereira, JM; Picotez, F; Clemente, A; Taveira, NOne anticapsid (p26) mouse monoclonal antibody was developed after immunization with recombinant p26 Gag protein and was tested for reactivity with different HIV-1 and HIV-2 isolates by ELISA and Western blot analysis. This antibody, named R26.1, reacted