2 documents found, page 1 of 1
Blood-brain barrier dysfunction in aging is mediated by brain endothelial senes...
Novo, João P.; Gee, Lucy; Caetano, Carolina A; Tomé, Inês; Vilaça, Andreia; von Zglinicki, Thomas; Moreira, Irina S; Jurk, Diana; Rosa, SusanaBBB dysfunction during aging is characterized by an increase in its permeability and phenotypic alterations of brain endothelial cells (BECs) including dysregulation of tight junction's expression. Here we have investigated the role of BEC senescence in the dysfunction of the BBB. Our results suggest that the transition from young to aged BBB is mediated, at least in part by BEC senescence.; SR acknowledges the...
Cellular and Molecular Mechanisms Mediating Methylmercury Neurotoxicity and Neu...
Novo, João P.; Martins, Beatriz; Raposo, Ramon S.; Pereira, Frederico C.; Oriá, Reinaldo B; Malva, João O.; Fontes-Ribeiro, CarlosMethylmercury (MeHg) toxicity is a major environmental concern. In the aquatic reservoir, MeHg bioaccumulates along the food chain until it is consumed by riverine populations. There has been much interest in the neurotoxicity of MeHg due to recent environmental disasters. Studies have also addressed the implications of long-term MeHg exposure for humans. The central nervous system is particularly susceptible t...