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Assessing Pharmaceutical Innovation in Europe: Therapeutic Advances vs. Unmet P...
Costa, Paula; Advinha, Ana Margarida; Oliveira-Martins, SofiaThis study presents a comprehensive characterization of novel medicines authorized by the European Commission (EC) between 2014 and 2024, with a focus on evaluating their innovative potential and therapeutic relevance. Beyond descriptive profiling, the study assesses the potential of innovation introduced by these novel drugs and address the alignment between therapeutic indications and unmet medical needs, as ...
Innovative Drug Access in Portugal: An Analysis of Managed Entry Agreements Sup...
Costa, Paula; Advinha, Ana Margarida; Oliveira-Martins, SofiaManaged Entry Agreements (MEAs) are tools designed to reduce clinical uncertainty and mitigate budget impact of often high-cost, innovative medicines. While finance-based MEAs have been widely used, the increasing complexity of therapies has driven the adoption of more sophisticated and tailored agreements, including risk-sharing models. This study aims to characterize the MEAs established to support public cov...
Innovative Medicines: An Analysis of EMA Approvals from the Perspective of Acti...
Costa, Paula; Advinha, Ana Margarida; Oliveira-Martins, SofiaInnovative Medicines: An Analysis of EMA Approvals from the Perspective of Active Substances
Production of sustainable aviation fuel precursors using the oleaginous yeast R...
Saraiva Lopes da Silva, Maria Teresa; Dutra, Francisca; Gomes, Miguel; Costa, Paula; Paradela, Filipe; Ferreira, Frederico CasteloABSTRACT: Sustainable aviation fuels (SAF) obtained from renewable sources of carbon can reduce carbon dioxide emissions and contribute for mitigating climate changes. In the present study, the yeast Rhodotorula toruloides PYCC 5615 was found to be highly promising for the bioconversion of eucalyptus bark hydrolysate and the accumulation of intracellular lipids which were further thermochemically processed to b...
Sustainable synthesis and optimisation of ethyl oleate from high oleic acid was...
Soares, Ana; Fontes, Ana Luiza; Teixeira, Francisca; Costa, Paula; Pimentel, Lígia; Pintado, Manuela; Rodríguez-Alcalá, Luis MiguelEthyl oleate (EO) is a versatile compound with several industrial applications, such as a vaccine adjuvant, an emollient in cosmetics, and a key component in food products as an additive used for pretreatment in preservation processes such as drying, while preserving valuable nutrients. Ethyl oleate is primarily synthesised from edible oils, which raises concerns regarding competition with food production. This...
Portugal Offshore Wind, Green Hydrogen, and Sustainable Fuels: Power-to-X Pathways
Simoes, Sofia; Portillo, Juan C. C.; Simões, Teresa; Estanqueiro, Ana; Catarino, Justina; Costa, Paula; Oliveira, Paula; Ribeiro Pinto, Paulo JorgeABSTRACT: Portugal has a vast coastal area and significant offshore wind resources. The country has set ambitious targets and designated specific areas for offshore wind development. Current national policies are actively encouraging investment in these projects. This report compiles the latest strategies for offshore wind and green hydrogen in Portugal. It introduces the Power-to-X (P2X) concept, explores pote...
Electrical driven pyrolysis reactor retrofit for indirect concentrated solar heat
Azevedo, Pedro; Costa, PaulaABSTRACT: Aiming for a climate-neutral economy, and the associated transition towards fuels produced from alternative feedstock, and to overcome some biomass pyrolysis unsuitable properties for the conventional combustion devices, plastics pyrolysis also produces oils, whose main compounds are also hydrocarbons, that can be used in conventional engines without so complex and costly upgrading processes. Most of ...
Carbon footprint assessment of microalgal biomass production, hydrothermal liqu...
Pires, Renata; Silva, Tiago; Ribeiro, Cláudia; Costa, Luis; Matos, Cristina T.; Costa, Paula; Lopes, Tiago; Gírio, Francisco; Silva, CarlaABSTRACT: Industrial liquid effluents (e.g., from fertilizer industry) and flue gas streams (e.g., CO2-rich, from cement industry) arise as an opportunity for waste valorization. Microalgae are suitable biomass for assimilating both effluents at the cultivation stage. Under a biorefinery concept, given the urge for energy transition in the aviation sector, this research explores the transformation of a microalg...
Project 3.3 -Task 1 Report - Literature review: Hydrogen transport options for ...
Costa, Paula; Portillo, Juan C. C.; Simoes, SofiaABSTRACT: Among the different applications in which hydrogen technology has become the protagonist, the transport sector should be particularly mentioned. It is expected that, by 2030, 1 in 12 cars sold in Germany, Japan, California, and South Korea will be powered by hydrogen, and that more than 350,000 hydrogen trucks will be able to transport large quantities of goods, while thousands of trains and ships can...
Biofuel from wastewater-grown microalgae: A biorefinery approach using hydrothe...
Silva, Thiago; de Aguiar do Couto, Eduardo; Assemany, Paula; Costa, Paula; Marques, Paula; Paradela, Filipe; Reis, Alberto; Calijuri, Maria LuciaABSTRACT: Third-generation biofuels from microalgae are becoming necessary for sustainable energy. In this context, this study explores the hydrothermal liquefaction (HTL) of microalgae biomass grown in wastewater, consisting of 30% Chlorella vulgaris, 69% Tetradesmus obliquus, and 1% cyanobacteria Limnothrix planctonica, and the subsequent upgrading of the produced bio-oil. The novelty of the work lies in inte...