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Nebivolol Increases Nitric Oxide Synthase via beta(3) Adrenergic Receptor in En...
Bueno-Pereira, Thaina Omia [UNESP]; Nunes, Priscila Rezeck [UNESP]; Matheus, Mariana Bertozzi [UNESP]; Vieira da Rocha, Ananda Lini [UNESP]Made available in DSpace on 2022-04-28T17:23:19Z (GMT). No. of bitstreams: 0 Previous issue date: 2022-03-01; Background: Low bioavailability of nitric oxide (NO) is related to the pathophysiology of preeclampsia (PE). In the present study, we investigated the effect of nebivolol (NEB), a beta(3)-receptor agonist with vasodilator properties, on the NO synthesis in endothelial cells incubated with plasma from pr...
Vitamin D modulates the transcription factors of T cell subsets to anti-inflamm...
Ribeiro, Vanessa Rocha [UNESP]; Romao-Veiga, Mariana [UNESP]; Nunes, Priscila Rezeck [UNESP]; Matias, Mariana Leticia [UNESP]Made available in DSpace on 2022-04-29T08:36:39Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-01-01; Vitamin D (VD) is a multifunctional prohormone and low VD status in pregnancy may contribute to the risk of adverse perinatal outcomes, such as preeclampsia (PE). This molecule may modulate the polarization of T cell subsets during gestation. This study evaluated the in vitro immunomodulatory effect of ...
DAMPs are able to skew CD4+ T cell subsets and increase the inflammatory profil...
Romao-Veiga, Mariana [UNESP]; Ribeiro, Vanessa Rocha [UNESP]; Matias, Mariana Leticia [UNESP]; Nunes, Priscila Rezeck [UNESP]Made available in DSpace on 2022-04-29T08:38:07Z (GMT). No. of bitstreams: 0 Previous issue date: 2022-02-01; Preeclampsia (PE) is characterized by abnormal activation of the immune system. The intense systemic inflammatory reaction, could be related to the presence of molecules released after cell stress or death, that are capable of inducing inflammation and are known as damage-associated molecular patterns (...
Immunomodulatory effect of vitamin D on the STATs and transcription factors of ...
Ribeiro, Vanessa Rocha [UNESP]; Romao-Veiga, Mariana [UNESP]; Nunes, Priscila Rezeck [UNESP]; de Oliveira, Larissa Ragozo Cardoso [UNESP]Made available in DSpace on 2022-04-29T08:38:14Z (GMT). No. of bitstreams: 0 Previous issue date: 2022-01-01; ASCRS Research Foundation; This study evaluated the in vitro modulatory effect of vitamin D (VD) on T cells, by determining the expression of STATs and the transcription factors of each CD4+ T cell subsets. Twenty women with preeclampsia (PE) and 20 normotensive pregnant women were studied. Peripheral b...
Increase of autophagy marker p62 in the placenta from pregnant women with preec...
Ribeiro, Vanessa Rocha [UNESP]; Romao-Veiga, Mariana [UNESP]; Nunes, Priscila Rezeck [UNESP]; Peracoli, Jose Carlos [UNESP]Made available in DSpace on 2022-04-29T08:39:57Z (GMT). No. of bitstreams: 0 Previous issue date: 2022-01-01; Preeclampsia (PE) is a multisystemic disorder characterized by abnormal placentation. Autophagy is a lysosomal degradation pathway that removes protein aggregates and damaged organelles, and it seems to be essential for cell survival during stress, hypoxia, and for implantation and development of the pl...
Association between Adverse Maternal Clinical Outcomes and Imbalance of Cytokin...
Nunes, Priscila Rezeck [UNESP]; Romao-Veiga, Mariana [UNESP]; Borges, Vera Therezinha Medeiros [UNESP]; Matias, Mariana Leticia [UNESP]Made available in DSpace on 2022-05-01T09:47:32Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-09-01; Objective Preeclampsia (PE) is a pregnancy-specific syndrome characterized by abnormal levels of cytokines and angiogenic factors, playing a role in the disease development. The present study evaluated whether immunological markers are associated with the gestational age and with the disease severity in...
Vitamin D decreases cell death and inflammation in human umbilical vein endothe...
Nunes, Priscila Rezeck [UNESP]; Romao-Veiga, Mariana [UNESP]; Ribeiro, Vanessa Rocha [UNESP]; de Oliveira, Larissa Ragozo Cardoso [UNESP]Made available in DSpace on 2022-05-01T11:54:05Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-01-01; This study evaluated the impact of vitamin D on Human Umbilical Vein Endothelial Cells (HUVEC) and inflammation in placental explants from women with preeclampsia (PE). HUVEC and explants from 10 late-onset PE (LOPE), 10 early-onset (EOPE), and 10 normotensive (NT) pregnant women were cultured with/with...
Progesterone and vitamin D downregulate the activation of the NLRP1/NLRP3 infla...
Matias, Mariana Leticia [UNESP]; Romao-Veiga, Mariana [UNESP]; Ribeiro, Vanessa Rocha [UNESP]; Nunes, Priscila Rezeck [UNESP]Made available in DSpace on 2021-06-25T10:52:06Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-04-01; This study evaluated the in vitro modulatory effect of progesterone (PG) and vitamin D (VD) on NLRP1/NLRP3 inflammasomes and TLR4/NF-κB pathway in monocytes from pregnant women with preeclampsia (PE). Monocytes from 20 preeclamptic and 20 normotensive (NT) pregnant women, and THP-1 cells were cultured w...
Silibinin induces in vitro M2-like phenotype polarization in monocytes from pre...
Gomes, Virgínia Juliani [UNESP]; Nunes, Priscila Rezeck [UNESP]; Matias, Mariana Letícia [UNESP]; Ribeiro, Vanessa Rocha [UNESP]Made available in DSpace on 2021-06-25T11:05:11Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-12-01; Preeclampsia (PE) is a pregnancy-specific syndrome featuring intense activation of circulating monocytes and an imbalance between pro- and anti-inflammatory cytokines. The present study evaluated the immunomodulatory effect of silibinin (Sb) on the expression of surface markers and the nuclear transcrip...
Silibinin downregulates the NF-κB pathway and NLRP1/NLRP3 inflammasomes in mono...
Matias, Mariana Leticia [UNESP]; Gomes, Virginia Juliani [UNESP]; Romao-Veiga, Mariana [UNESP]; Ribeiro, Vanessa Rocha [UNESP]Made available in DSpace on 2019-10-06T17:08:12Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-04-19; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Preeclampsia (PE) is a human pregnancy-specific syndrome with abnormal activation of cells from the innate immune system. The present study evaluated whether silibinin (SB) treatment of monocytes from preeclamptic women could modulate NLRP1 ...