8 documents found, page 1 of 1
Evidência de dano precoce da cartilagem na osteoartrite experimental por meio d...
Girão-Carmona, Virgínia Cláudia Carneiro; Bezerra, Mirna Marques; Porto, Fernanda Maria Aragão Ximenes; Pinto, Ana Carolina Matias DinellyImages obtained by scanning electron microscopy of articular cartilage samples from mice submitted to an experimental model of osteoarthritis for semiquantitative analysis.; Imagens obtidas por microscopia eletrônica de varredura de amostras de cartilagem articular de camundongos submetidos a modelo experimental de osteoartrite para análise semiquantitativa.
Caracterização ultraestrutural da cartilagem articular em modelo experimental d...
Porto, Fernanda Maria Aragão Ximenes; Rocha, Francisco Airton Castro da; Pinto, Ana Carolina Matias Dinely; Nunes, Rodolfo de MeloEm estudos anteriores demonstramos que camundongos submetidos a meniscotomia desenvolvem osteoartrite (OA) mais grave e sintomática com marcante sinovite que camundongos submetidos à retirada do menisco (meniscectomia). Nesse trabalho, buscamos determinar as características ultraestruturais de lesões articulares presentes no modelo de OA por meniscotomia através de técnicas de microscopia eletrônica de varredur...
Cell sources of inflammatory mediators present in bone marrow areas inside the ...
Rocha, Francisco Airton Castro; Girão, Virgínia Claudia Carneiro; Nunes, Rodolfo de Melo; Pinto, Ana Carolina Matias Dinelly; Vidal, BrunoPurpose: To demonstrate the production of inflammatory mediators by cells located in bone marrow spaces inside rodent menisci. Methods: Mice subjected to transection of the medial collateral and anterior cruciate ligaments and meniscotomy (osteoarthritis model) or to a sham procedure, as well as non-operated (naive) mice and rats, had knee joints excised. Tissues were stained with hematoxylin-eosin and tartrate...
Alterações fenotípicas dos glicosaminoglicanos provenientes de cartilagem osteo...
Nunes, Rodolfo de MeloOsteoarthritis (OA) is a chronic degenerative disease where there seems to be an imbalance between the synthesis and degradation of the articular cartilage. It is associated with chronic pain and functional disability. However, the manifestation of these two signs characterizes a chronic and advanced, since in humans, the lack of objective and reliable methods to evaluate the evolution of OA limits its clinical...
Tumor necrosis factor prevents Candida albicans biofilm formation
Rocha, Francisco Airton Castro; Alves, Anelise Maria Costa Vasconcelos; Rocha, Marcos Fábio Gadelha; Cordeiro, Rossana de Aguiar CordeiroCandida species are commensals but some develop biofilms in prosthetic materials and host surfaces that may represent up to 30% of deaths related to infections, particularly in immunosuppressed patients. Tumor necrosis factor (TNF) exhibits a plethora of functions in host defense mechanisms whereas excessive release of TNF in inflammation promotes tissue damage. Cytokines released in an inflammatory milieu may ...
Strontium ranelate analgesia in arthritis models is associated to decreased cyt...
Nunes, Rodolfo de Melo; Martins, Morgana Ramos; Silva Junior, Francisco Saraiva da; Leite, Ana Caroline Rocha de Melo; Girão, Virgínia Cláudia CarneiroObjective We investigated the anti-inflammatory activity of strontium ranelate (SR) in arthritis models. Materials and methods Rats received 1 mg zymosan (Zy) or saline intra-articularly. Other groups were subjected to anterior cruciate ligament transection in the right knee, as an osteoarthritis (OA) model, or a sham procedure. Joint pain was assessed using the articular incapacitation and paw-pressure tests. ...
Vitamin D levels in juvenile idiopathic arthritis from an equatorial region
Studart, Sâmia Araújo de Sousa; Leite, Ana Caroline Rocha de Melo; Marinho, Aryana Lushese Lima Feitosa; Pinto, Ana Carolina Matias DinellyWe aimed to describe the serum levels of 25-hydroxyvitamin D (25OHD) in juvenile idiopathic arthritis (JIA) patients living in a low-latitude (3°43′S) region. Fifty JIA patients, 31 (62 %) female, seen between May 2012 and April 2013 in the northeast of Brazil had clinical data and serum collected for determination of 25OHD and parathyroid hormone (PTH) using a chemiluminescent ELISA; 20 age- and sex-matched co...
Avaliação qualitativa e quantitativa de glicosaminoglicanos em pacientes com os...
Nunes, Rodolfo de MeloArticular cartilage is na avascular tissue composed of chondrocytes scattered in an abundant extracellular matrix (ECM) that lines the joint surfaces and protects the bone ends. In addition to the intersticial fluid, the ECM is composed of proteoglycans, glycosaminoglycans (GAGs) and glycoproteins. Joint diseases such as osteoarthritis (OA), promote the degradation of articular cartilage and subchondral bone sc...