26 documents found, page 1 of 3
Non-destructive evaluation of the steel fibre content and anisometry in thin UH...
Mário Jorge Pimentel; Sine, A; Nunes, SThe tensile response of ultra-high performance fibre-reinforced composites (UHPFRC) is decisive in many applications and depends on the steel fibre content and orientation. These vary troughout the structural element and may differ from those in the laboratory specimens used to characterize the material behaviour. This work presents the developments on a non-destructive test method based on the measurement of t...
HIV-1-Transmitted Drug Resistance and Transmission Clusters in Newly Diagnosed ...
Pingarilho, M; Pimentel, V; Miranda, M; Silva, AR; Diniz, A; Ascenção, B; Piñeiro, C; Koch, C; Rodrigues, C; Caldas, C; Morais, C; Faria, DObjective: To describe and analyze transmitted drug resistance (TDR) between 2014 and 2019 in newly infected patients with HIV-1 in Portugal and to characterize its transmission networks. Methods: Clinical, socioepidemiological, and risk behavior data were collected from 820 newly diagnosed patients in Portugal between September 2014 and December 2019. The sequences obtained from drug resistance testing were us...
Caracterização de Crianças com Distúrbio do Espectro da Neuropatia Auditiva e s...
Mariano, M; Correia, I; Nunes, S; Cunha, I; Sousa, H; Kay, T; Barros, EObjectivos: Identificar e caracterizar os casos pediátricos de Distúrbio do Espectro da Neuropatia Auditiva (DENA) e analisar a sua reabilitação. Desenho do Estudo: Estudo observacional descritivo. Material e Métodos: Análise dos processos clínicos de 671 doentes avaliados em primeira consulta de reabilitação auditiva pediátrica entre 2012 e 2019. Dos 467 casos de hipoacusia sensorioneural, incluíram-se aqueles...
Perfil Genético da Surdez: Reabilitação Auditiva e Fatores Preditivos de Prognó...
Pereira, S; Nunes, S; Mariano, M; Sousa, H; Lavra, T; Kay, T; Barros, EObjetivos: Caracterizar a população com surdez de etiologia genética, a relação genótipo-fenótipo e fatores prognósticos na decisão de tratamento de reabilitação. Material e Métodos: Análise retrospetiva da população pediátrica referenciada da consulta de Reabilitação Auditiva à consulta de Genética Médica entre janeiro-2012 e dezembro-2017. Resultados: Foram encaminhadas 128 crianças e o estudo genético foi po...
Crescent-like lesions as an early signature of nephropathy in a rat model of pr...
Nunes, S; Alves, A; Preguiça, I; Barbosa, A; Vieira, P; Mendes, F; Martins, D; Viana, SD; Reis, FDiabetic nephropathy (DN) is a major microvascular complication of diabetes. Obesity and hyperlipidemia, fueled by unhealthy food habits, are risk factors to glomerular filtration rate (GFR) decline and DN progression. Several studies recommend that diabetic patients should be screened early (in prediabetes) for kidney disease, in order to prevent advanced stages, for whom the current interventions are clearly ...
Ionic Liquid-Assisted Synthesis of Mesoporous Silk Fibroin/Silica Hybrids for B...
Pereira, R; Zehbe, K; Günter, C; Santos, T; Nunes, S; Paz, F; Silva, M; Granja, PL; Taubert, A; De Zea Bermudez, VNew mesoporous silk fibroin (SF)/silica hybrids were processed via a one-pot soft and energy-efficient sol-gel chemistry and self-assembly from a silica precursor, an acidic or basic catalyst, and the ionic liquid 1-butyl-3-methylimidazolium chloride, acting as both solvent and mesoporosity-inducer. The as-prepared materials were obtained as slightly transparent-opaque, amorphous monoliths, easily transformed i...
BRAF V600E Mutation and 9p21: CDKN2A/B and MTAP Co-Deletions - Markers in the C...
Frazão, L; Martins, MC; Nunes, VM; Pimentel, J; Faria, C; Miguéns, J; Sagarribay, A; Matos, M; Salgado, D; Nunes, S; Mafra, M; Roque, LGenetic alterations in pediatric primary brain tumors can be used as diagnostic and prognostic markers and are the basis for the development of new target therapies that, ideally, would be associated with lower mortality and morbidity. This study evaluates the incidence and interplay of the presence of BRAF V600E mutation and chromosomal 9p21 deletions in a series of 100 pediatric gliomas, aiming to determine t...
Protocol for a randomised, double-masked, sham-controlled phase 4 study on the ...
Marques, JP; Farinha, C; Costa, MÂ; Ferrão, Â; Nunes, S; Silva, RPURPOSE: The purpose of this study is to compare the efficacy and safety of intravitreal aflibercept (IVA) with sham photodynamic therapy (sPDT) versus IVA with verteporfin PDT (vPDT) in a Caucasian population with treatment-naive polypoidal choroidal vasculopathy (PCV), enrolling into a treat and extend (T&E) regimen. METHODS AND ANALYSIS: Randomised, double-masked, sham-controlled, multicentre phase 4 investi...
Characteristics and outcomes of heart failure hospitalization before implementa...
Marques, I; Abreu, S; Bertão, MV; Ferreira, B; Ramos, RL; Lopes, J; Nunes, S; Mendonça, D; Teixeira, LObjective: This study aims to characterize patients hospitalized for acute heart failure (HF) in an internal medicine department and their one-year mortality and rate of rehospitalization for decompensated HF. Methods: This retrospective observational study enrolled all patients discharged in 2012 after hospitalization for acute HF. Discharge summaries, clinical records and telephone interviews were analysed. T...
Tumor de Buschke-Löwenstein: um Caso em Doente com Coinfeção Vírus da Imunodefi...
Santos, L; Borges, N; Nunes, S; Ramos, J; Almeida, C; Paixão, IO tumor de Buschke-Löwenstein (TBL) é uma variante rara de condiloma acuminatum que possui comportamento maligno pelo crescimento local, mas não apresenta potencial metastático. Afeta primariamente a área genital e, menos frequentemente a região perianal. Os fatores de risco para o seu desenvolvimento incluem a terapêutica imunossupressora e a infeção VIH. Possui elevada taxa de recorrência e de transformação m...