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Antibacterial Photodynamic Inactivation of Antibiotic-Resistant Bacteria and Bi...

Vinagreiro, Carolina dos Santos; Zangirolami, Amanda; Schaberle, Fábio António; Nunes, Sandra Cristina da Cruz; Blanco, Kate C; Inada, Natalia M.

Gram-negative bacteria and bacteria in biofilms are very difficult to eradicate and are the most antibiotic-resistant bacteria. Therapeutic alternatives less susceptible to mechanisms of resistance are urgently needed to respond to an alarming increase of resistant nosocomial infections. Antibacterial photodynamic inactivation (PDI) generates oxidative stress that triggers multiple cell death mechanisms that ar...


Computational Approaches in Theranostics: Mining and Predicting Cancer Data

Cova, Tânia F. G. G.; Bento, Daniel J.; Nunes, Sandra Cristina da Cruz

The ability to understand the complexity of cancer-related data has been prompted by the applications of (1) computer and data sciences, including data mining, predictive analytics, machine learning, and artificial intelligence, and (2) advances in imaging technology and probe development. Computational modelling and simulation are systematic and cost-effective tools able to identify important temporal/spatial ...


Contribuição para o estudo da estrutura de antagonistas adrenérgicos - beta

Nunes, Sandra Cristina da Cruz

Tese de doutoramento em Química (Termodinâmica Química) apresentada à Fac. de Ciências e Tecnologia da Univ. de Coimbra


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