5 documents found, page 1 of 1
Zebrafish Avatar-test forecasts clinical response to chemotherapy in patients w...
Costa, Bruna; Estrada, Marta F.; Gomes, António; Fernandez, Laura M.; Azevedo, José M.; Póvoa, Vanda; Fontes, Márcia; Alves, António; Galzerano, AntónioCancer patients often undergo rounds of trial-and-error to find the most effective treatment because there is no test in the clinical practice for predicting therapy response. Here, we conduct a clinical study to validate the zebrafish patient-derived xenograft model (zAvatar) as a fast predictive platform for personalized treatment in colorectal cancer. zAvatars are generated with patient tumor cells, treated ...
THE USE OF A BIODEGRADABLE SELF-EXPANDABLE PROSTHESIS AS A SOLUTION FOR COLOREC...
Fagoso, Marta; Afonso, Énio; Oliveira, Ana; Nunes, VítorBenign colorectal strictures are usually treated by endoscopic dilation. The use of metallic stents is limited and not clear. Biodegradable stents initially developed for management of refractory esophageal benign strictures have an important advantage as they do not need to be removed. However, their use is yet to be validated in intestinal strictures. We report a case of a 25-year- old woman, with a sigmoid v...
A RARE CAUSE OF COLONIC PERFORATION
Martins, Ana Rita; Frazão, Joana; Pinto, Bruno; Godinho, António; Nunes, VítorThe use of biliary stent has become increasingly common in clinical practice. Sigmoid colon perforation from a migrated biliary stent is a rare complication. A high level of suspicion is essential for an adequate diagnosis, in which surgery have an essential role. We present a case of choledocholithiasis treated by endoscopic retrograde cholangiopancreatography with a biliary plastic stent placement. Subsequent...
Preoperative color Doppler ultrasound parameters for surgical decision-making i...
Gomes, António Pedro; Germano, Ana; Sousa, Marta; Martins, Rita; Coelho, Constança; Ferreira, Maria José; Rocha, Evangelista; Nunes, VítorObjective: Current scientific evidence is insufficient to determine the best vascular access for each patient. It is an unmet clinical need because vascular access dysfunction accounts for 20% to 30% of hospital admissions. Our aim was to evaluate preoperative color flow Doppler ultrasound (CDUS)-derived parameters (vein diameter and brachial artery flow and diameter) and their effect interaction with comorbidi...
Colonic mucinous adenocarcinoma with atypical metastasis
Tomás, Rita; Aleixo, Isabel; Martins, Carlos; Dias, Wilma; Nunes, VítorIn 2002 a right hemicolectomy was performed in a 70-year-old male with cecal cancer. Histologically it was a well-differenciated mucinous adenocarcinona (Dukes C stage, pT3pN1pMx, tumor free margins). Adjuvant therapy was chemotherapy. In January 2007, during the surgical treatment of right hidrocele testis, the discovery of a large hard mass determined a right orchidectomy. The result of the pathologic analysi...