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Muscle dysfunction in axial spondylarthritis: the MyoSpA study
Neto, Agna; Torres, R. Pinheiro; Ramiro, Sofia; Sardoo, A.; Rodrigues Manica, Santiago; Gomes, JL; Domingues, Lúcia; Crespo, Carolina; Teixeira, DianaObjective We aimed to investigate muscle physical properties, strength, mass, physical performance, and the prevalence of sarcopenia in patients with axial spondylarthritis (axSpA) compared to the healthy controls (HC). Methods We performed a cross-sectional study on 54 participants: 27 patients with axSpA and 27 HC, matched by age, gender, and level of physical activity. Muscle physical properties (stiffness, ...
The Effect of ACTN3 and VDR Polymorphisms on Skeletal Muscle Performance in Axi...
Pimenta, Isabel; Mateus, Hugo; Rodrigues Manica, Santiago; Pinheiro-Torres, Rita; Neto, Agna; Domingues, Lúcia; Crespo, Carolina; Sardoo, AtlasFunding Information: This study was supported by the funding through project MyoSpA, from iNOVA4 health. PM was supported by the National Institute for Health Research (NIHR) University College London Hospitals (UCLH) Biomedical Research Centre (BRC). Publisher Copyright: © Copyright © 2021 Pimenta, Mateus, Rodrigues-Manica, Pinheiro-Torres, Neto, Domingues, Lage Crespo, Sardoo, Machado, Branco, Silva and Pimen...
Lumbar myofascial physical properties in healthy adults
M. Pimentel-Santos, F.; Rodrigues Manica, Santiago; Alfonse, T. Masi; Gomes, JL; Baptista, Mariana; Ramiro, Sofia; Sepriano, Alexandre; Nair, K.Funding Information: Portuguese Society of Rheumatology grant. Publisher Copyright: © 2021, The Official Journal Of The Portuguese Society Of Rheumatology. All rights reserved.; Objective: The human resting myofascial tone maintains the body tone in a neutral posture, the assessment of this and other muscle physical properties (MPP) is relevant, since, it is altered in many pathological states. Patients and met...
Eligibility criteria for biologic disease-modifying antirheumatic drugs in axia...
Marona, José; Sepriano, Alexandre; Rodrigues Manica, Santiago; M. Pimentel-Santos, F.; Mourão, Ana Filipa; Gouveia, Nélia; Branco, Jaime; Santos, HelenaThis work was supported by a Research Grant from the InvestigatorInitiated Studies program of Merck Sharp & Dohme (Grant No. 56078). The sponsor did not interfere with the study question, analysis or interpretation of results. AS is supported by a doctoral grant from Fundação para a Ciência e Tecnologia (Foundation for Science and Technology) (SFRH/BD/108246/2015).; OBJECTIVES: To compare definitions of high di...
Effectiveness of switching between TNF inhibitors in patients with axial spondy...
Rodrigues Manica, Santiago; Sepriano, Alexandre; M. Pimentel-Santos, F.; Gouveia, Nélia; Barcelos, Anabela; Branco, Jaime; Bernardes, Miguel57763]. AS is supported by a doctoral grant from “Fundação para a Ciência e Tecnologia” (SFRH/BD/108246/2015).; Background: To investigate whether the reason to discontinue the first TNF inhibitor (TNFi) affects the response to the second TNFi in axial spondyloarthritis (axSpA). Methods: Patients with axSpA from the Rheumatic Diseases Portuguese Register (ReumaPt), who discontinued their first TNFi and started ...
Effect of biologic disease-modifying anti-rheumatic drugs targeting remission i...
Machado, Ana Rita; Rodrigues Manica, Santiago; Silva, Joana Leite; Alho, Irina; Coelho, Constança; Duarte, Joana; Florêncio, CláudiaObjectives: To assess the efficacy of biologic DMARDs (bDMARDs) in achieving Assessment of Spondyloarthritis International Society partial remission (ASAS-PR) and/or Ankylosing Spondylitis Disease Activity Score inactive disease (ASDAS-ID), as remission-like surrogates, in axial SpA (axSpA). Methods: Data from randomized controlled trials (RCTs), including long-term extensions, were included. A systematic liter...
Prognostic factors for recovery and non-recovery in patients with non-specific ...
Domingues, Lúcia; Cruz, Eduardo B.; M. Pimentel-Santos, F.; Ramiro, Sofia; Donato, Helena; Rodrigues Manica, Santiago; Hayden, Jill AlisonINTRODUCTION: Neck pain is a common musculoskeletal disorder worldwide. It can result in significant disability and impaired quality of life. More than 50% of patients with neck pain still report symptoms 1 year later despite receiving different forms of non-pharmacological and pharmacological treatment. Identifying patient characteristics that are modifiable or predict recovery and non-recovery for an individu...