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Antimicrobial activity of prophage endolysins against critical Enterobacteriace...
Gonçalves, Tiago; Marques, Andreia T.; Manageiro, Vera; Tanoeiro, Luis; Vital, Joana S.; Duarte, Aida; Vítor, Jorge M. B.; Caniça, ManuelaEnterobacteriaceae species are part of the 2017 World Health Organization antibiotic-resistant priority pathogens list for development of novel medicines. Multidrug-resistant Klebsiella pneumoniae is an increasing threat to public health and has become a relevant human pathogen involved in life-threatening infections. Phage therapy involves the use of phages or their lytic endolysins as bioagents for the treatm...
Molecular detection of Helicobacter pyloriand its genotypic antimicrobial resis...
Ismail, Muhammad Ahamed; Majaliwa, Nashon D.; Vale, Filipa F.; Cumbana, Roqueia; Sumbana, José J.; Muchongo, Arsénio; Nassone, Ema; Loforte, MichellaBackground Helicobacter pylori strains show a high level of genotypic diversity and express several genes that contribute to their pathogenicity and resistance. In Mozambique, there is lack of information regarding its resistance pattern to antibiotics. In this study, we aimed to investigate the prevalence of H. pylori and its genotypic resistance to clarithromycin, metronidazole, and fluoroquinolones in Mozamb...
Cellular and Enzymatic Determinants Impacting the Exolytic Action of an Anti-St...
Gouveia, Ana; Pinto, Daniela; Vítor, Jorge M. B.; São-José, CarlosBacteriophage endolysins are bacteriolytic enzymes that have been explored as potential weapons to fight antibiotic-resistant bacteria. Despite several studies support the application of endolysins as enzybiotics, detailed knowledge on cellular and enzymatic factors affecting their lytic activity is still missing. The bacterial membrane proton motive force (PMF) and certain cell wall glycopolymers of Gram-posit...
Molecular detection of Helicobacter pylori and its genotypic antimicrobial resi...
Ismail, Muhammad; Majaliwa, Nashon D.; Vale, Filipa F.; Cumbana, Roqueia; Sumbana, José J.; Muchongo, Arsénio; Nassone, Ema; Loforte, MichellaBackground Helicobacter pylori strains show a high level of genotypic diversity and express several genes that contribute to their pathogenicity and resistance. In Mozambique, there is lack of information regarding its resistance pattern to antibiotics. In this study, we aimed to investigate the prevalence of H. pylori and its genotypic resistance to clarithromycin, metronidazole, and fluoroquinolones in Mozamb...
Liposomal Delivery of Newly Identified Prophage Lysins in a Pseudomonas aerugin...
Morais, Diana; Tanoeiro, Luis; Marques, Andreia T.; Gonçalves, Tiago; Duarte, Aida; Matos, António Pedro Alves; Vital, Joana S.Pseudomonas aeruginosa is a Gram-negative opportunistic bacterium that presents resistance to several antibiotics, thus, representing a major threat to human and animal health. Phage-derived products, namely lysins, or peptidoglycan-hydrolyzing enzymes, can be an effective weapon against antibiotic-resistant bacteria. Whereas in Gram-positive bacteria, lysis from without is facilitated by the exposed peptidogly...
Liposomal Delivery of Newly Identified Prophage Lysins in a Pseudomonas aerugin...
Morais, Diana; Tanoeiro, Luís; Marques, Andreia; Gonçalves, Tiago; Duarte, A.; Matos, António; Vital, Joana; Cruz, Maria Eugénia MeirinhosPseudomonas aeruginosa is a Gram-negative opportunistic bacterium that presents resistance to several antibiotics, thus, representing a major threat to human and animal health. Phage-derived products, namely lysins, or peptidoglycan-hydrolyzing enzymes, can be an effective weapon against antibiotic-resistant bacteria. Whereas in Gram-positive bacteria, lysis from without is facilitated by the exposed peptidogly...
Cryptic Prophages Contribution for Campylobacter jejuni and Campylobacter coli ...
Tanoeiro, Luis; Oleastro, Mónica; Nunes, Alexandra; Marques, Andreia T.; Duarte, Sílvia Vaz; Gomes, João Paulo; Matos, António Pedro AlvesCampylobacter coli and C. jejuni, the causing agents of campylobacteriosis, are described to be undergoing introgression events, i.e., the transference of genetic material between different species, with some isolates sharing almost a quarter of its genome. The participation of phages in introgression events and consequent impact on host ecology and evolution remain elusive. Three distinct prophages, named C. j...
Cryptic Prophages Contribution for Campylobacter jejuni and Campylobacter coli ...
Tanoeiro, Luis; Oleastro, Mónica; Nunes, Alexandra; Marques, Andreia T.; Duarte, Sílvia Vaz; Gomes, João Paulo; Matos, António Pedro AlvesCampylobacter coli and C. jejuni, the causing agents of campylobacteriosis, are described to be undergoing introgression events, i.e., the transference of genetic material between different species, with some isolates sharing almost a quarter of its genome. The participation of phages in introgression events and consequent impact on host ecology and evolution remain elusive. Three distinct prophages, named C. j...
Cryptic prophages contribution for Campylobacter jejuni and Campylobacter coli ...
Tanoeiro, Luís; Oleastro, Mónica; Nunes, Alexandra; Marques, Andreia T.; Duarte, Sílvia Vaz; Gomes, João Paulo; Matos, António Pedro AlvesCampylobacter coli and C. jejuni, the causing agents of campylobacteriosis, are described to be undergoing introgression events, i.e., the transference of genetic material between different species, with some isolates sharing almost a quarter of its genome. The participation of phages in introgression events and consequent impact on host ecology and evolution remain elusive. Three distinct prophages, named C. j...
Liposomal delivery of newly identified prophage lysins in a Pseudomonas aerugin...
Morais, Diana; Tanoeiro, Luís; Marques, Andreia T.; Gonçalves, Tiago; Duarte, Aida; Matos, António Pedro Alves; Vital, Joana S.Pseudomonas aeruginosa is a Gram-negative opportunistic bacterium that presents resistance to several antibiotics, thus, representing a major threat to human and animal health. Phage-derived products, namely lysins, or peptidoglycan-hydrolyzing enzymes, can be an effective weapon against antibiotic-resistant bacteria. Whereas in Gram-positive bacteria, lysis from without is facilitated by the exposed peptidogly...