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Impact of malocclusion, tooth loss and oral hygiene habits on quality of life i...

Pereira, D; Machado, V; Botelho, J; Proença, L; Rua, J; Lemos, C; Mendes, JJ; Delgado, AS

We aimed to assess the impact of malocclusion on oral health-related quality of life (OHRQoL) in a sample composed of adolescents, younger adults and adults seeking orthodontic treatment. Participants were consecutively enrolled from January 2019 to March 2020. The oral health impact profile (OHIP-14) was used to measure the OHRQoL. The index of complexity, outcome and need (ICON) was used to assess malocclusio...



Global Ultrasound Check for the Critically lll (GUCCI)-a new systematized proto...

Tavares, J; Ivo, R; Gonzalez, F; Lamas, T; Mendes, JJ

Ultrasound technology is an essential tool in the management of critically ill patients. Point-of-care ultrasonography (POCUS) enables data collection from different anatomic areas to achieve the most probable diagnosis and administer the right therapy at the right time. Despite the increasing utilization of POCUS, there is still a lack of standards to establish how to use different bedside ultrasound protocols...

Date: 2019   |   Origin: Saúde - CUF

Molecular Typing, Virulence Traits and Antimicrobial Resistance of Diabetic Foo...

Mottola, C; Semedo-Lemsaddek, T; Mendes, JJ; Melo-Cristino, J; Tavares, L; Cavaco-Silva, P; Oliveira, M

Diabetes mellitus is a major chronic disease that continues to increase significantly. One of the most important and costly complications of diabetes are foot infections that may be colonized by pathogenic and antimicrobial resistant bacteria, harboring several virulence factors, that could impair its successful treatment. Staphylococcus aureus is one of the most prevalent isolate in diabetic foot infections, t...


Susceptibility Patterns of Staphylococcus Aureus Biofilms in Diabetic Foot Infe...

Mottola, C; Matias, C; Mendes, JJ; Melo-Cristino, J; Tavares, L; Cavaco-Silva, P; Oliveira, M

BACKGROUND: Foot infections are a major cause of morbidity in people with diabetes and the most common cause of diabetes-related hospitalization and lower extremity amputation. Staphylococcus aureus is by far the most frequent species isolated from these infections. In particular, methicillin-resistant S. aureus (MRSA) has emerged as a major clinical and epidemiological problem in hospitals. MRSA strains have t...


In Vitro Design of a Novel Lytic Bacteriophage Cocktail with Therapeutic Potent...

Mendes, JJ; Leandro, C; Mottola, C; Barbosa, R; Silva, F; Oliveira, M; Vilela, C; Melo-Cristino, J; Górski, A; Pimentel, M; São-José, C; Cavaco-Silva, P

In patients with diabetes mellitus, foot infections pose a significant risk. These are complex infections commonly caused by Staphylococcus aureus, Pseudomonas aeruginosa and Acinetobacter baumannii, all of which are potentially susceptible to bacteriophages. Here, we characterized five bacteriophages that we had determined previously to have antimicrobial and wound-healing potential in chronic S. aureus, P. ae...


Diabetic Foot Infections: Current Diagnosis and Treatment

Mendes, JJ; Neves, J

Diabetes mellitus (DM) is a global epidemic, and diabetic foot ulcer (DFU) is one of its most serious and costly complications. DFUs result from a complex interaction of a number of risk factors. Once the protective layer of skin is broken, deep tissues are exposed to bacterial infection that progresses rapidly. Patients with DFUs frequently require amputations of the lower limbs and, in more than half the case...


A Rat Model of Diabetic Wound Infection for the Evaluation of Topical Antimicro...

Mendes, JJ; Leandro, C; Bonaparte, D; Pinto, A

Diabetes mellitus is an epidemic multisystemic chronic disease that frequently is complicated by complex wound infections. Innovative topical antimicrobial therapy agents are potentially useful for multimodal treatment of these infections. However, an appropriately standardized in vivo model is currently not available to facilitate the screening of these emerging products and their effect on wound healing. To d...


Clinical and Bacteriological Survey of Diabetic Foot Infections in Lisbon

Mendes, JJ; Marques-Costa, A; Vilela, C; Neves, J; Candeias, N; Cavaco-Silva, P; Melo-Cristino, J

AIMS: An epidemiological survey of diabetic foot infections (DFIs) in Lisbon, stratifying the bacterial profile based on patient demographical data, diabetic foot characteristics (PEDIS classification), ulcer duration and antibiotic therapy. METHODS: A transversal observational multicenter study, with clinical data collection using a structured questionnaire and microbiological products (aspirates, biopsies or ...


Miocardiopatia Não Compactada. Revisão a Propósito de Oito Casos

Toste, A; Branco, LM; Galrinho, A; Lousinha, A; Fiarresga, A; Oliveira, MM; Abreu, J; Mendes, JJ; Ferreira, ML; Leal, A; Cruz Ferreira, R

A miocardiopatia não compactada isolada é uma doença geneticamente determinada cuja patogénese parece envolver uma paragem no desenvolvimento do endomiocárdio. Morfologicamente caracteriza-se pela presença de trabeculações proeminentes separadas por profundos recessos preenchidos por fluxo e como tal por Doppler a cor no estudo ecocardiográfico. No sentido de melhor caracterizar esta entidade recentemente descr...


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