2 documents found, page 1 of 1
D-2-hydroxyglutarate supports a tolerogenic phenotype with lowered major histoc...
Hammon, Kathrin; Renner, Kathrin; Althammer, Michael; Voll, Florian; Babl, Nathalie; Decking, Sonja-Maria; Siska, Peter J.; Matos, CarinaD-2-hydroxyglutarate (D-2-HG) accumulates in primary acute myeloid leukemia (AML) patients with mutated isocitrate dehydrogenase (IDH) and other malignancies. D-2-HG suppresses antitumor T cell immunity but little is known about potential effects on non-malignant myeloid cells. Here we show that D-2-HG impairs human but not murine dendritic cell (DC) differentiation, resulting in a tolerogenic phenotype with lo...
Phylogeography of Y-chromosome haplogroup I reveals distinct domains of Prehist...
Rootsi, Siiri; Kivisild, Toomas; Benuzzi, Giorgia; Help, Hela; Bermisheva, Marina; Kutuev, Ildus; Barać, Lovorka; Peričić, Marijana; Balanovsky, OlegTo investigate which aspects of contemporary human Y-chromosome variation in Europe are characteristic of primary colonization, late-glacial expansions from refuge areas, Neolithic dispersals, or more recent events of gene flow, we have analyzed, in detail, haplogroup I (Hg I), the only major clade of the Y phylogeny that is widespread over Europe but virtually absent elsewhere. The analysis of 1,104 Hg I Y chr...