5 documents found, page 1 of 1
Evaluation of partial thromboplastin time, thrombin time and prothrombin time o...
Miranda, Vanessa Maria Andrade Machado; Barbosa Filho, José Pedro Martins; Costa, Romero Marcos Pedrosa Brandão; Leite, Ana Cristina LimaFibrinolytic proteases are enzymes that degrade the fibrin, a main component of the blood clot. Thus, the present study aimed to understand the evaluation of aPTT, TT and PT on plasma treated with a fibrinolytic protease produced by Mucor subtillissimus. To assess the anticoagulant effect, the protease was used in different concentrations of 0.5-2.5mg/mL. The tests showed that the enzyme promoted a significant ...
Anti-liver cancer activity in vitro and in vivo induced by 2-pyridyl 2,3-thiazo...
Silva, Thiago David dos Santos; Bomfim, Larissa Mendes; Rodrigues, Ana Carolina Borges da Cruz; Dias, Rosane Borges; Sales, Caroline Brandi SchlaepferSubmitted by Renorbio (renorbioba@ufba.br) on 2018-05-02T18:48:24Z No. of bitstreams: 1 ANTI-LIVER CANCER ACTIVITY IN VITRO AND IN VIVO INDUCED BY 2-PYRIDYL 2,3-THIAZOLE DERIVATIVES.pdf: 2793458 bytes, checksum: fcbb9a4336522af9d68dd7cdd4ded487 (MD5); Approved for entry into archive by Delba Rosa (delba@ufba.br) on 2018-05-04T14:23:31Z (GMT) No. of bitstreams: 1 ANTI-LIVER CANCER ACTIVITY IN VITRO AND IN VIVO I...
Cytotoxic and toxicological effects of phthalimide derivatives on tumor and nor...
Ferreira, Paulo Michel Pinheiro; Costa, Patrícia Marçal da; Costa, Arinice de Menezes; Lima, Daisy Jereissati Barbosa; Drumond, Renata RosadoEleven phthalimide derivatives were evaluated with regards to their antiproliferative activity on tumor and normal cells and possible toxic effects. Cytotoxic analyses were performed against murine tumors (Sarcoma 180 and B-16/F-10 cells) and peripheral blood mononuclear cells (PBMC) using MTT and Alamar Blue assays. Following, the investigation of cytotoxicity was executed by flow cytometry analysis and antitu...
Production of intravenous human dengue immunoglobulin from Brazilian-blood donors
Gouveia, Frederico Leite; Oliveira, Renata Mendes Batista de; Lucena, Antônio Edson de Souza; Cordeiro, Marli Tenório; Leite, Ana Cristina LimaA dengue representa um importante problema de saúde no Brasil, portanto, a identificação de vacina ou tratamento eficaz é uma necessidade urgente. A neutralização do vírus da dengue, por anticorpo específico, tem potencial aplicação terapêutica. Descrevemos aqui, pela primeira vez, a preparação de imunoglobulina específica para o vírus da dengue (IgG anti-DENV), produzida a partir do plasma selecionado de doado...
A new methodology for polyvalent intravenous immunoglobulin solution production...
Lucena, Antônio Edson de Souza; Sampaio, Divaldo de Almeida; Silva, Ednaldo Rosas da; Paiva, Virgínia Florêncio de; Santiago, Ana CláudiaHighly purified intravenous immunoglobulin G concentrate (IV IgG) was produced with the use of polyethylene glycol associated to a single-stage precipitation by ethanol, instead of the classic Cohn-Oncley process, which employs cold alcohol as the precipitating agent, in a three-stage process. Precipitation of crude fraction containing more than 95% of immunoglobulin G was performed by liquid chromatography wit...