Introduction: Adrenal insufficiency is a clinical condition that may be due to multiple pathologies that affect the adrenal glands' synthesis and/or secretion of cortisol. The clinical presentation can vary from an adrenal crisis (acute adrenal insufficiency) to a gradual onset of non-specific symptoms (chronic adrenal insufficiency). In this article, we describe the case of a patient who developed symptoms of ...
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Objective: Malignant melanoma (MM) is among the most lethal skin cancers, with early diagnosis being essential for timely treatment and favorable prognosis. The coronavirus disease 19 (COVID-19) pandemic-related disruptions in global healthcare systems affected cancer screening and treatment. The aim of this study was to investigate the potential impact of the COVID-19 pandemic on the diagnosis and prognosis of...
The Iberian Peninsula, in southwestern Europe, is home to a distinctive freshwater fish fauna, predominantly composed of endemic species. This is a consequence of the prolonged isolation from western Europe caused by the Pyrenees, the diverse geological and climatic gradients, and the isolation of river basins. Freshwater and diadromous fishes have diversified in the Iberian Peninsula and include 72 currently r...
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Episodic memory decline is a major signature of both normal and pathological aging. Many neural regions have been implicated in the processes subserving both episodic memory and typical aging decline. Here, we demonstrate that the cerebellum is causally involved episodic memory under aging. We show that a 12-day neurostimulation program delivered to the right cerebellum led to improvements in episodic memory pe...
Throughout history, the use of animals for agricultural and forestry work has been closely associated with human societies, with multiple references to animal power being utilized for various tasks since the Neolithic period. However, the advent of industrialization has fundamentally transformed the reality of society, leading to a significant shift towards the mechanization of processes. Despite this, animal t...
Normal brain functioning depends on metals homeostasis, as imbalances may increase oxidative stress and cause other detrimental intracellular events that lead to cell loss. Furthermore, environmental exposure to toxic metals is hypothesized to induce neuroinflammation and neuropathology, paving the way to neurodegeneration. The aim of this study was to examine whether such Potentially Toxic Elements (PTE) are a...