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In Vivo Antimicrobial Activity of Nisin Z Against S. aureus and Polyurea Pharma...

Serrano, Isa; Mil-Homens, Dalila; Pires, Rita F.; Bonifácio, Vasco D. B.; Guerreiro, Joana F.; Cunha, Eva; Costa, Sofia S.; Tavares, Luís

Funding Information: This research was funded by national funds from the Fundação para a Ciência e a Tecnologia (FCT) (Projects PTDC/SAUINF/28466/2017 and PTDC/MEC-ONC/29327/2017); by the FCT in the scope of CIISA–Centro de Investigação Interdisciplinar em Sanidade Animal, Faculdade de Medicina Veterinária, Universidade de Lisboa (Project UIDB/00276/2020), and Laboratório Associado para Ciência Animal e Veterin...


An Innovative Approach to Estimate Infection by COVID-19

Oliveira, Manuela; Garção, Eugénio; Grilo, Luís M.; Mexia, João T.

Publisher Copyright: © 2024 American Institute of Physics Inc.. All rights reserved.; Given that individuals in a certain population are different (among other things they have a different immune system), it is possible that some are infected with the known virus COVID-19 and are asymptomatic and therefore not diagnosed with the disease. Thus, estimates of the number of infected and dead with COVID-19 may not c...


Postingestive reward acts through behavioral reinforcement and is conserved in ...

Ribeiro, Gabriela; Fernandes, Ana B.; Oliveira, Francisco P.M.; Duarte, João S.; Oliveira, Manuela; Limbert, Clotilde; Costa, Rui M.; Costa, Durval C.

Funding Information: GR was funded by doctoral fellowships from Universidade de Lisboa (BD/2015Call) and Funda\u00E7\u00E3o para a Ci\u00EAncia e Tecnologia (FCT; https:// www.fct.pt/; SFRH/BD/128783/2017). GR and AJOM were supported by the Champalimaud Foundation through a Clinical Kickstarter grant (https://www.fchampalimaud.org/). ABF was supported by a postdoctoral fellowship (SFRH/BPD/880972/2012) and is s...


Full survival of Galleria mellonella infected with Staphylococcus aureus after ...

Serrano, Isa; Mil-Homens, Dalila; Guerreiro, J. F.; Cunha, Eva; Costa, SS; Tavares, Luís; Oliveira, Manuela

Diabetes mellitus affects nearly 6.4% of the worldwide population, and this number may double by 2030. Up to 25% of diabetic patients may develop diabetic foot ulcers (DFUs). Among DFU patients, 80% will suffer lower-limb amputations due to diabetic foot infections (DFIs), which are generally colonized by polymicrobial biofilms. Staphylococcus aureus is the DFIs’ predominant pathogen, frequently found together ...


IgG+ Extracellular Vesicles Measure Therapeutic Response in Advanced Pancreatic...

Couto, Nuno; Elzanowska, Julia; Maia, Joana; Batista, Silvia; Pereira, Catarina Esteves; Beck, Hans Christian; Carvalho, Ana Sofia

Funding Information: J.E. was supported by grant 765492 from H2020-MSCA-ITN-2017. J.M. was supported by “Fundação para a Ciência e a Tecnologia” (PD/BD/105866/2014). S.B. was supported by the EMBO Installation Grant 3921. This work was supported by the Champalimaud Foundation and grant LCF/PR/HR19/52160014 from “La Caixa” Foundation. M.O.’s research is partially supported by National Funds through FCT, Fundação...


New Insights on Streptococcus dysgalactiae subsp. dysgalactiae Isolates

Alves-Barroco, Cinthia; Caço, João; Roma-Rodrigues, Catarina; Fernandes, Alexandra R.; Bexiga, Ricardo; Oliveira, Manuela; Chambel, Lélia

Streptococcus dysgalactiae subsp. dysgalactiae (SDSD) has been considered a strict animal pathogen. Nevertheless, the recent reports of human infections suggest a niche expansion for this subspecies, which may be a consequence of the virulence gene acquisition that increases its pathogenicity. Previous studies reported the presence of virulence genes of Streptococcus pyogenes phages among bovine SDSD (collected...


Putative probiotic lactic acid bacteria isolated from sauerkraut fermentations

Touret, Tiago; Oliveira, Manuela; Semedo-Lemsaddek, Teresa

Probiotics are live microorganisms which confer health benefits to the host, and may be isolated from several sources, such as vegetable foodstuffs. Sauerkraut is a cabbage product resulting from fermentation by a lactic acid bacteria microbial succession, and is a potential source for probiotics. The aim of the present study was the isolation and characterization of probiotic microorganisms from sauerkraut fer...


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