7 documents found, page 1 of 1
A Giant Gastric Lipoma
Oliveira, AI; Lopes, V; Barbosa, JP; Barbosa, E; José Barbosa
Increased 30-Day Mortality in Very Old ICU Patients with COVID-19 Compared to P...
Guidet, B; Jung, C; Flaatten, H; Fjølner, J; Artigas, A; Bollen Pinto, B; Schefold, J; Beil, M; Sigal, S; Vernon van Heerden, P; Szczeklik, WPurpose: The number of patients ≥ 80 years admitted into critical care is increasing. Coronavirus disease 2019 (COVID-19) added another challenge for clinical decisions for both admission and limitation of life-sustaining treatments (LLST). We aimed to compare the characteristics and mortality of very old critically ill patients with or without COVID-19 with a focus on LLST. Methods: Patients 80 years or older ...
Assessing the Effects of the Transition from Multiple Daily Insulin Injections ...
Oliveira, SC; Neves, C; Esteves, C; Neves, JS; Oliveira, AI; Pereira, M; Arteiro, Cristina; Costa, A; Redondo, MD; Baltazar, R; Carvalho, DavideIntroduction: Intensive insulin therapy is currently the main treatment in type I diabetes mellitus (DM) which includes multiple daily insulin injections (MDI) and continuous subcutaneous insulin infusion (CSII). The latter has become the preferred therapeutic mode, since it better mimics the physiological pancreatic action, althought there is limited evidence that supports its superiority to MDI. The aim of ou...
Ectopic Cushing's Syndrome Unveiling a Metastatic Parotid Carcinoma
Oliveira, SC; Neves, JS; Souteiro, P; Belo, S; Oliveira, AI; Moreira, H; Gomes, PM; Coelho, L; Sarmento, C; Fonseca, E; Neves, C; Freitas, PIntroduction. Adrenocorticotropic hormone (ACTH) ectopic production is a rare cause of Cushing syndrome (CS). The most commonly associated tumours are small-cell lung carcinoma along with bronchial and thymic carcinoids. To date, only 5 cases have been published in the literature featuring ectopic ACTH secretion from metastatic acinic cell carcinoma (ACC) of the parotid gland. We hereby describe a very uncommon...
Comment on Bress et al. Effect of Intensive Versus Standard Blood Pressure Trea...
Neves, J; Vieira, M; Leitão, L; Dias, C; Magriço, R; Oliveira, AI; Carvalho, D
Effects of the functional HOTAIR rs920778 and rs12826786 genetic variants in gl...
Xavier-Magalhães, A; Oliveira, AI; Vieira de Castro, J; Pojo, M; Gonçalves, CS; Lourenço, T; Viana-Pereira, M; Costa, S; Linhares, P; Vaz, R; Nabiço, RAbnormal expression of the long non-coding RNA HOX transcript antisense intergenic RNA (HOTAIR) is oncogenic in several human cancers, including gliomas. The HOTAIR single nucleotide polymorphisms (SNPs) rs920778 (C > T) and rs12826786 (C > T) present in the intronic enhancer and promoter regions of HOTAIR, respectively, are associated with expression, cancer susceptibility, and patient prognosis in some tumor ...
A transcriptomic signature mediated by HOXA9 promotes human glioblastoma initia...
Pojo, M; Gonçalves, CS; Xavier-Magalhães, A; Oliveira, AI; Gonçalves, T; Correia, S; Rodrigues, AJ; Costa, S; Pinto, L; Pinto, AA; Lopes, JM; Reis, RMGlioblastoma is the most malignant brain tumor, exhibiting remarkable resistance to treatment. Here we investigated the oncogenic potential of HOXA9 in gliomagenesis, the molecular and cellular mechanisms by which HOXA9 renders glioblastoma more aggressive, and how HOXA9 affects response to chemotherapy and survival. The prognostic value of HOXA9 in glioblastoma patients was validated in two large datasets from...