14 documents found, page 1 of 2
Anti-malarial activity and toxicity of Aspidosperma nitidum Benth: a plant used...
Brandão, Dayse Lucia do Nascimento; Martins, Michel Tavares; Silva, Adreanne Oliveira; Almeida, Amanda Dias; Paula, Renata Cristina deThe objective of this work was to evaluate the antiplasmodial activity and toxicity of the extract and fractions obtained from the bark of Aspidosperma nitidum. The ethanol extract obtained from the powdered bark of plants was acid-base partitioned and phytochemically analyzed. The antiplasmodial activity, in vivo antimalarial activity and in vitro cytotoxicity were acessed. The selectivity index (SI) was calcu...
Antioxidant study indicative of antibacterial and antimutagenic activities of a...
Diaz, Marisa Alves Nogueira; Fietto, Luciano Gomes; Leite, João Paulo Viana; Gontijo, Douglas Costa; Gontijo, Pablo Costa; Brandão, Geraldo CélioEthnopharmacological relevance; Several plant species of Miconia genus are commonly used in Brazilian folk medicine as anti-inflammatory agents and for the treatment of infectious diseases. Infusions and extracts of Miconia species are also reported as analgesic, antimicrobial, antimalarial, antioxidant, anti-inflammatory, antinociceptive, antimutagenic, and antitumoral. To determine the phytochemical compositi...
Estudo de modelagem molecular de complexos ferriprotoporfirina-IX e quinolinoca...
Silva, Thais Horta Álvares da; Oliveira, Marcelo Tavares de; Santos, Hélio Ferreira dos; Oliveira, Alaíde Braga de; Almeida, Wagner Batista de-; Quinine and quinidine are well-known 4-quinolinecarbinolamines that exhibit antimalarial activity, but, in contrast, their epimers 9-epiquinine and 9-epiquinidine are almost inactive. Literature data are conflicting in describing the 4-quinolinecarbinolamine interaction mode with the molecular target, the ferriprotoporphyrin IX [Fe(III)PPIX]. In the present paper, a pharmacophore is proposed based on the bin...
Identification of phenolic compounds and biologically related activities from O...
Gontijo, Douglas Costa; Brandão, Geraldo Célio; Gontijo, Pablo Costa; Oliveira, Alaíde Braga de; Diaz, Marisa Alves Nogueira; Fietto, Luciano GomesOcotea odorifera (Vell.) Rohwer is popularly used as food and flavoring. The aim of this study was to determine the chemical composition of the aqueous extract from O. odorifera leaves and evaluate the correlation of their phytochemical composition and biological activities. The antioxidant effect was determined by DPPH radical scavenging, β-carotene-linoleic acid and lipid peroxidation assays; the antibacteria...
Identification of phenolic compounds and biologically related activities from O...
Gontijo, Douglas da Costa; Brandão, Geraldo Célio; Gontijo, Pablo Costa; Oliveira, Alaíde Braga de; Diaz, Marisa Alves Nogueira; Fietto, Luciano GomesOcotea odorifera (Vell.) Rohwer is popularly used as food and flavoring. The aim of this study was to determine the chemical composition of the aqueous extract from O. odorifera leaves and evaluate the correlation of their phytochemical composition and biological activities. The antioxidant effect was determined by DPPH radical scavenging, b-carotene-linoleic acid and lipid peroxidation assays; the antibacteria...
Antiviral activity of Fridericia formosa (Bureau) L. G. Lohmann (Bignoniaceae) ...
Brandão, Geraldo Célio; Kroon, Erna Geessien; Souza Filho, José Dias de; Oliveira, Alaíde Braga deA phytochemical study of Fridericia formosa (Bignoniaceae) ethanol extracts of leaves, stems, and fruits was guided by in vitro assays against vaccinia virus Western Reserve (VACV-WR), human herpes virus 1 (HSV-1), murine encephalomyocarditis virus (EMCV), and dengue virus type 2 (DENV-2) by the MTT method. All the ethanol extracts were active against DENV-2, HSV-1, and VACV-WRwith best results for the fruits e...
Synthesis by click reactions and antiplasmodial activity of Lupeol 1,2,3-Triazo...
Borgati, Tatiane Freitas; Pereira, Guilherme Rocha; Brandão, Geraldo Célio; Santos, Juliana de Oliveira; Fernandes, Dayane Aparecida MoraisLupeol, a triterpene frequently found in Asteraceae plant species, showed moderate to low activity in different strains of Plasmodium falciparum, the most virulent malaria etiological agents. In this work, lupeol was isolated from Parahancornia fasciculata, a plant that is used to treat malaria in the Amazonia region. In the search of more activity lupeol derivatives, five new 1,2,3-triazole hybrid molecules we...
Chemical constituents of Distictella elongata (Vahl) Urb. (Bignoniaceae).
Simões, Leandro R.; Maciel, Glauber M.; Brandão, Geraldo Célio; Souza Filho, José Dias de; Oliveira, Alaíde Braga de; Castilho, Rachel OliveiraPectolinarina, uma flavona heterosídica, foi isolada do extrato etanólico das folhas de Distictella elongata (Vahl) Urb., além de uma mistura de ácidos ursólico, pomólico e oleanólico, além de β-sitosterol. Suas estruturas foram estabelecidas com base em análise espectral (RMN de 1H e 13C 1D e 2D) em comparação com a literatura. Esta é a primeira vez em que se relata a ocorrência deste flavonoide em uma espécie...
Anti-malarial activity and toxicity assessment of Himatanthus articulatus, a pl...
Vale, Valdicley Vieira; Vilhena, Thyago da Costa; Trindade, Rafaela Cabral dos Santos; Ferreira, Márlia Regina C.; Percário, SandroBackground: Plasmodium falciparum has become resistant to some of the available drugs. Several plant species are used for the treatment of malaria, such as Himatanthus articulatus in parts of Brazil. The present paper reports the phyto-chemistry, the anti-plasmodial and anti-malarial activity, as well as the toxicity of H. articulatus. Methods: Ethanol and dichloromethane extracts were obtained from the powder ...
In vitro antitumor activity of sesquiterpene lactones from Lychnophora trichoca...
Guimarães, Dênia Antunes Saúde; Raslan, Delio Soares; Oliveira, Alaíde Braga deAs lactonas sesquiterpênicas licnofolida e eremantolida C foram isoladas de Lychnophora trichocarpha Spreng. (Asteraceae), espécie vegetal nativa do cerrado brasileiro e popularmente conhecida por arnica brasileira. As lactonas sesquiterpênicas são conhecidas por apresentarem variadas atividades biológicas, incluindo atividade antitumoral. O presente artigo relata a avaliação da atividade antitumoral in vitro d...