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Cyclodextrin-complexed Ocimum basilicum leaves essential oil increases fos prot...
Nascimento, Simone de Souza; Araujo, Adriano Antunes de Souza; Brito, Renan Guedes de; Serafini, Mairim Russo; Menezes, Paula dos PassosO. basilicum leaves produce essential oils (LEO) rich in monoterpenes. The short half-life and water insolubility are limitations for LEO medical uses. β-Cyclodextrin (β-CD) has been employed to improve the pharmacological properties of LEO. We assessed the antihyperalgesic profile of LEO, isolated or complexed in β-CD (LEO/β-CD), on an animal model for fibromyalgia. Behavioral tests: mice were treated every da...
Cyclodextrin-complexed Ocimum basilicum leaves essential oil increases Fos prot...
Nascimento, Simone de Souza; Araujo, Adriano Antunes de Souza; Brito, Renan Guedes de; Serafini, Mairim Russo; Menezes, Paula dos PassosO. basilicum leaves produce essential oils (LEO) rich in monoterpenes. The short half-life and water insolubility are limitations for LEO medical uses. β-Cyclodextrin (β-CD) has been employed to improve the pharmacological properties of LEO. We assessed the antihyperalgesic profile of LEO, isolated or complexed in β-CD (LEO/β-CD), on an animal model for fibromyalgia. Behavioral tests: mice were treated every da...