2 documents found, page 1 of 1
Utilização das técnicas de imuno-histoquímica e reação em cadeia da polimerase ...
Soares, Carlos Eduardo Lopes; Xavier, Pâmela Maria Martins da Silva; Oliveira, Ana Cláudia da Silva Mendes de; Gerson, GunterIntroduction: Lung cancer is a cancer of high incidence and mortality. The identification of PD-L1 immunoexpression has enabled new treatments with monoclonal antibodies, and the PCR technique for researching EGFR changes allows indicating treatment with tyrosine kinase inhibitors. Objective: to evaluate the immunohistochemical profile and EGFR changes in a series of lung cancer samples. Methodology: Retrospect...
Avaliação da mutação de EGFR e da imunoexpressão de ALK e de PD-L1 em Adenocarc...
Oliveira, Ana Cláudia da Silva Mendes deLung cancer is one the most frequent cause of cancer death in Brazil and worldwide. The advent of new drugs directed towards specific molecular alterations, such as anti-tyrosine kinase for EGFR mutation (Epidermal Growth Factor Receptor) and for the rearrangement of the ALK (Anaplastic Lymphoma Kinase) gene and immunotherapy for PD-L1 (Cell Death Ligant 1 Receptor)expression brought an important gain in overal...