95 documents found, page 1 of 10
Innovative processing and sterilization techniques to unlock the potential of s...
Veiga, Anabela; Ramírez-Jiménez, Rosa Ana; Santos-Rosales, Víctor; García-González, Carlos A.; Aguilar, Maria Rosa; Rojo, Luis; Oliveira, Ana L.Silk sericin (SS), a by-product of the textile industry, has gained significant attention for its biomedical potential due to its biocompatibility and regenerative potential. However, the literature lacks information on SS processing methods and the resulting physicochemical properties. This study represents the first step in protocol optimization and standardization. In the present work, different processing t...
Cutting-edge hybrid dressings: combining silk medical textiles and decellulariz...
Sousa, Teresa; Vale, Inês; Rosadas, Marta; Silva, Inês V.; Ribeiro, Viviana P.; Oliveira, Ana L.Aim: Burns affect 11 million people globally each year, with 180,000 fatalities [1]. This study investigates a multilayer burn dressing combining silk fibroin (SF) fabric with highly- preserved decellularized porcine small intestine (dPSI) to support tissue regeneration and wound integration [2]. A silk sericin (SS) hydrogel is included as interface for structural integrity and anti-inflammatory benefits, enhan...
Sugarcane straw hemicellulose extraction by autohydrolysis for cosmetic applica...
Pereira, Maria João; Pedrosa, Sílvia S.; Costa, Joana R.; Carvalho, Maria João; Neto, Tânia; Oliveira, Ana L.; Pintado, Manuela; Madureira, Ana RaquelSugarcane is a popular crop whose cultivation generates a wide range of by-products. The aim was to optimize the hydrothermal extraction of hemicellulose from sugarcane straw using response-surface methods with a two-factor composite design and to assess its functional qualities. Three process parameters were subject to optimization: solid/liquid ratio (1:6–1:18), temperature (143–186 °C), and extraction time (...
Dual and sequential drug delivery systems with antimicrobial and bone regenerat...
Rodrigues, Miguel A.; Ferreira, Carla; Borges, João P.; Bernardes, Beatriz G.; Oliveira, Ana L.; Santos, José D.; Lopes, Maria A.Bone defect healing is often compromised by infections acquired during surgery, hindering regeneration. An effective solution should first prevent infection and then promote bone repair. Localised drug-delivery systems capable of dual and sequential release of antimicrobial and bone-regenerative agents represent a promising solution; however, precisely controlling this sequential release remains an unmet challe...
Biofunctional silk sericin hydrogels: a versatile platform with potential for t...
Veiga, Anabela; Ribeiro, Viviana; Ramírez-Jiménez, Rosa Ana; Aguilar, Maria Rosa; Rojo, Luis; Oliveira, Ana L.Discarded silk sericin protein (SS) presents a high yet underexplored potential as a biomaterial for tissue engineering (TE). Despite its biocompatibility, antioxidant activity, and moisture retention properties, its poor stability in aqueous media has limited broader application. In this work, we developed and characterized SS-based hydrogels using tannic acid (TA) and horseradish peroxidase (HRP) crosslinking...
Development of a decellularized extracelular matrix from porcine aorta for hear...
Reis, Mariana S.; Rosadas, Marta; Ho, Chou I.; Sousa, Teresa; Pazmino, Carlos; Costa, João; Vervenne, Thibault; Oliveira, Ana L.; Ribeiro, Viviana P.Cardiovascular diseases are the leading cause of adult mortality worldwide, according to the World Health Organization [1]. An important surgical approach for treating diseased aortic valves is the Ross procedure, in whic the affected aortic valve is replaced with an autograft from the patient’s own pulmonary valve.
Biohybrid dressings: integrating silk fibroin textiles with decellularized biol...
Sousa, Teresa; Vale, Inês; Rosadas, Marta; Silva, Inês V.; Ribeiro, Viviana P.; Oliveira, Ana L.Burns affect 11 million people globally each year with 180,000 associated fatalities. This study proposes a multilayer hybrid dressing combining a silk fibroin (SF) textile with decellularized porcine small intestine (dPSI) capable of simultaneously provide wound protection and tissue regeneration. A silk sericin (SS) hydrogel was embedded into the decellularized tissue ensuring the integration with the textile...
Development of a decellularized extracelular matrix from porcine aorta for hear...
Reis, Mariana S.; Rosadas, Marta; Ho, Chou I.; Costa, João; Vervenne, Thibault; Oliveira, Ana L.; Ribeiro, Viviana P.; Mignon, ArnCardiovascular diseases are the leading cause of adult mortality worldwide, according to the WHO [1]. An important surgical approach for treating diseased aortic valves is the Ross procedure, in which the affected aortic valve is replaced with an autograft from the patient’s own pulmonary valve. The main concern about this procedure is linked to wall dilatation, which can lead to valve leakage and reoperation. ...
Exploring rabbit skin as a novel decellularized dermal substitute for burn woun...
Rosadas, Marta; Sousa, Teresa; Silva, Inês V.; Sousa, Alda; Ribeiro, Viviana P.; Oliveira, Ana L.Aim: Burn wounds represent a significant medical challenge. Autografts remain the standard treatment, however, are unsuitable for deep or extensive burns(1). Decellularized skin xenografts offer a viable alternative, having significantly reduced immunogenicity, still there is currently no skin-derived decellularized xenografic matrix due to its low resemblance to human skin (2)(3). This study proposes decellula...
Effects of protein conformational transition accompanied with crosslinking dens...
Cai, Guolong; Zhao, Weikun; Zhu, Tianhao; Oliveira, Ana L.; Yao, Xiang; Zhang, YaopengSilk fibroin (SF) hydrogels possess excellent biocompatibility and biomimetic properties of the extracellular matrix. Among them, the mild chemical crosslinked SF hydrogels show great application potential in the fields of 3D cell culture and tissue repairing and thus have attracted widespread attention. However, the mobility of hydrophobic chain segments of SF molecules in these chemical crosslinked hydrogels ...