2 documents found, page 1 of 1
Ring-Fused meso-Tetraarylchlorins as Auspicious PDT Sensitizers: Synthesis, Str...
Laranjo, Mafalda; Pereira, Nelson A. M.; Oliveira, Andreia S. R.; Aguiar, Márcia Campos; Brites, Gonçalo Sousa; Nascimento, Bruno F. O.Novel 4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-fused meso-tetraarylchlorins, with different degrees of hydrophilicity (with methyl ester, hydroxymethyl, and carboxylic acid moieties), have been synthesized and their photophysical characterization as well as in vitro photocytotoxicity assessment against human melanoma and esophageal and bladder carcinomas was carried out. An integrated analysis of the photosens...
Targeting triple-negative breast cancer cells with 6,7-bis(hydroxymethyl)-1H,3H...
Santos, Kathleen; Laranjo, Mafalda; Abrantes, Ana Margarida; Brito, Ana F.; Gonçalves, Cristina; Ribeiro, Ana Bela Sarmento; Botelho, M. FilomenaFurther studies on 6,7-bis(hydroxymethyl)-1H,3H-pyrrolo[1,2-c]thiazoles as anticancer agents against breast cancer are reported, allowing to demonstrate the potential of these compounds for the therapy of the triple-negative breast cancer, the most challenging tumors in clinical practice. These compounds were assayed for their in vitro cytotoxicity on several human breast cancer cell lines (MCF7, HCC1954 and HC...