5 documents found, page 1 of 1
Lack of microsatellite instability in gastrointestinal stromal tumors
Campanella, Nathália C.; Scapulatempo-Neto, Cristovam; Abrahão-Machado, Lucas Faria; Oliveira, Antônio Talvane Torres; Berardinelli, Gustavo N.The microsatellite instability (MSI) phenotype may constitute an important biomarker for patient response to immunotherapy, particularly to anti-programmed death-1 inhibitors. MSI is a type of genomic instability caused by a defect in DNA mismatch repair (MMR) proteins, which is present mainly in colorectal cancer and its hereditary form, hereditary nonpolyposis colorectal cancer. Gastrointestinal stromal tumor...
Low frequency of TERT promoter mutations in gastrointestinal stromal tumors (GI...
Reis, R. M.; Campanella, Nathália C.; Celestino, Ricardo; Pestana, Ana; Scapulatempo-Neto, Cristovam; Oliveira, Antônio Talvane TorresSomatic mutations in the promoter region of telomerase reverse transcriptase (TERT) gene, mainly at positions c. − 124 and c. − 146 bp, are frequent in several human cancers; yet its presence in gastrointestinal stromal tumor (GIST) has not been reported to date. Herein, we searched for the presence and clinicopathological association of TERT promoter mutations in genomic DNA from 130 bona fide GISTs. We found ...
Co-expression of monocarboxylate transporter 1 (MCT1) and its chaperone (CD147)...
Oliveira, Antônio Talvane Torres; Pinheiro, Céline; Filho, A. L.; Brito, Maria José; Martinho, Olga; Matos, Delcio; Carvalho, André LopesMonocarboxylate transporters (MCTs) have been described to play an important role in cancer, but to date there are no reports on the significance of MCT expression in gastrointestinal stromal tumors (GISTs). The aim of the present work was to assess the value of MCT expression, as well as co-expression with the MCT chaperone CD147 in GISTs and evaluate their clinical-pathological significance. We analyzed the i...
Lymphangiogenic VEGF-C and VEGFR-3 expression in genetically characterised gast...
Oliveira, Antônio Talvane Torres; Reis, R. M.; Afonso, Julieta Alexandra Pereira; Martinho, Olga; Matos, Delcio; Carvalho, André LopesThis study aimed to assess the distribution of VEGF-C and VEGFR-3 expression in gastrointestinal stromal tumours (GISTs), and to analyse the value of lymphatic vessel density (LVD) in a tumour that is believed to preferentially metastasize through blood vessel conduits. A panel of immunohistochemical antibodies was used to evaluate 51 cases of genetically characterised GISTs: VEGF-C, VEGFR-3, D2-40 (for LVD ass...
MET Is highly expressed in advanced stages of colorectal cancer and indicates w...
Oliveira, Antônio Talvane Torres; Matos, Delcio; Logullo, Angela Flavio; Silva, Sandra Regina Morini da; Neto, Ricardo ArtigianiThe aim of the present study was to evaluate by immunohistochemistry the prognostic meaning of the tumor marker MET (hepatocyte growth factor) in patients submitted to surgical resection due to primary colorectal adenocarcinoma. PATIENTS AND METHODS: A retrospective study was carried out that included 286 consecutive patients with colorectal adenocarcinoma, submitted to surgical resection at Barretos Cancer Hos...