2 documents found, page 1 of 1
Biological evaluation of isoniazid derivatives as an anticancer class
Rodrigues, Felipe A. R.; Oliveira, Augusto C. A.; Cavalcante, Bruno C.; Pessoa, Claudia; Pinheiro, Alessandra C.; Souza, Marcus V. N. deA series of thirty-two isoniazid derivatives have been evaluated for their activity against four human cancer cell lines with potent cytotoxicity (IC50 ranging from 0.61 to 3.36 μg/mL). The structure-activity relationship (SAR) analysis indicated the number, the positions, and the types of substituents attached to the aromatic ring as being critical factors for the biological activity. Briefly, we observed that...
Cytotoxic evaluation of substituted benzaldehydes
Rodrigues, Felipe A. R.; Oliveira, Augusto C. A.; Cavalcanti, Bruno C.; Costa, Marcília P.; Pessoa, Claudia; Souza, Marcus V. N. deA series of fifty-four commercial aldehydes have been synthesized and evaluated for their activity against peripheral blood mononuclear cells (PBMC) and four human cancer cell lines, exhibiting potent citotoxicity (IC50 ranging from 0.36 to 4.75 μg mL-1). The structureactivity relationship (SAR) analysis indicated that the number, the positions and the type of substituents attached into the aromatic and heteroa...