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Immune cellular profile of bisphosphonate-related osteonecrosis of the jaw
Silva, Paulo Goberlândio de Barros; Oliveira, C. C. de; Brizeno, Luiz André Cavalcante; Wong, Deysi V. T.; Lima Júnior, Roberto César PereiraOBJECTIVES: Characterize the cell profile and immunostaining of proinflammatory markers in an experimental model of bisphosphonate-related osteonecrosis of the jaw (BRONJ). MATERIALS AND METHODS: Male Wistar rats (n = 6-7) were treated chronically with saline solution or zoledronic acid (ZA) at 0.04, 0.20, and 1.00 mg kg(-1) (1.4 × 10(-7) , 6.9 × 10(-6) , and 3.4 × 10(-5) mol kg(-1) ), and subsequently, the fir...
Date: 2017
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Origin: Oasisbr