2 documents found, page 1 of 1
New supramolecular hydrogels based on diastereomeric dehydrotripeptide mixtures...
Oliveira, Carlos B. P.; Carvalho, André; Pereira, Renato B.; Pereira, David M.; Hilliou, L.; Jervis, Peter J.; Martins, J. A. R.; Ferreira, Paula M. T.Self-assembly of peptide building blocks offers unique opportunities for bottom-up preparation of exquisite nanostructures, nanoarchitectures, and nanostructured bulk materials, namely hydrogels. In this work we describe the synthesis, characterization, gelation, and rheological properties of new dehydrotripeptides, Cbz-L-Lys(Cbz)-L,D-Asp-∆Phe-OH and (2-Naph)-L-Lys(2-Naph)-L,D-Asp-∆Phe-OH, containing a N-termin...
Aryl-capped lysine-dehydroamino acid dipeptide supergelators as potential drug ...
Oliveira, Carlos B. P.; Pereira, Renato B.; Pereira, David M.; Hilliou, L.; Castro, Tarsila Gabriel; Martins, J. A. R.; Jervis, Peter JohnEmploying amino acids and peptides as molecular building blocks provides unique opportunities for generating supramolecular hydrogels, owing to their inherent biological origin, bioactivity, biocompatibility, and biodegradability. However, they can suffer from proteolytic degradation. Short peptides (<8 amino acids) attached to an aromatic capping group are particularly attractive alternatives for minimalistic ...