11 documents found, page 1 of 2

Qualidade de vida de idosos brasileiros e portugueses: uma análise comparativa ...

Introdução: A longevidade tornou-se uma das maiores conquistas da segunda metade do século XX. Objetivo: Comparar a qualidade de vida de idosos brasileiros e portugueses usuários da atenção primária à saúde. Materiais e Métodos: Estudo quantitativo, transversal e comparativo, aplicado a amostra probabilística englobando 294 idosos acompanhados pela Saúde da Família divididos em dois grupos: 130 idosos em Benevi...

Clinical Trials in Portugal: How Can we Improve?

miRNA-31 Improves Cognition and Abolishes Amyloid-β Pathology by Targeting APP ...

Alzheimer's disease (AD) is the most common form of dementia worldwide, characterized by progressive memory impairment, behavioral changes, and, ultimately, loss of consciousness and death. Recently, microRNA (miRNA) dysfunction has been associated with increased production and impaired clearance of amyloid-β (Aβ) peptides, whose accumulation is one of the most well-known pathophysiological markers of this dise...

Addition of the Aβ42/40 ratio to the cerebrospinal fluid biomarker profile incr...

Background: Cerebrospinal fluid (CSF) biomarkers have been used to increase the evidence of underlying Alzheimer’s disease (AD) pathology in mild cognitive impairment (MCI). However, CSF biomarker-based classification often results in conflicting profiles with controversial prognostic value. Normalization of the CSF Aβ42 concentration to the level of total amyloid beta (Aβ), using the Aβ42/40 ratio, has been sh...

Relevant Factors on Cognitive Evaluation of the Portuguese Population

Introduction: Aging is an inevitable process that has a social impact in the forecoming decades, and it will present a great challenge regarding public health. An efficient health system requires a reflection on the preventive measures to be implemented.Material and Methods: The study population comprised a total number of 2672 individuals of both genders, aged 55 years and over, residents in continental Portug...

Chasing the Effects of Pre-Analytical Confounders - A Multicenter Study on CSF-...

Introduction: Core cerebrospinal fluid (CSF) biomarkers – Aβ42, Tau, and phosphorylated Tau (pTau) – have been recently incorporated in the revised criteria for Alzheimer’s disease (AD). However, their widespread clinical application lacks standardization. Preanalytical sample handling and storage play an important role in the reliable measurement of these biomarkers across laboratories. Aim: In this study, we ...

Pain management in neonatal intensive care unit: translating research evidence ...

A socio-demographic study of aging in the Portuguese Population - The EPEPP study

The increase in life expectancy (LE) observed in Western societies, has resulted in a steep rise of older population. This stresses the importance of the research on aging, to better adequate health and social care organization and improve the quality of life (QoL). The aim of the EPEPP-1 (abbreviated from the Portuguese name: Estudo do Perfil de Envelhecimento da Populac¸a˜o Portuguesa) study was to characteri...

Neurotoxic effect of oligomeric and fibrillar species of A<beta>1-42 peptide. I...

http://www.sciencedirect.com/science/article/B6T0F-4SSY90W-1/1/0b10903f573d4beaec42f0dc791857e3

Insulin affects synaptosomal GABA and glutamate transport under oxidative stres...

In this study, we investigated the in vitro effect of exogenously administered insulin on the susceptibility to oxidative stress and on the accumulation of the amino acid neurotransmitters [gamma]-aminobutyric acid (GABA) and glutamate in a synaptosomal fraction isolated from male Wistar rat brain cortex. Insulin (1 [mu]M) did not affect synaptosomal lipid peroxidation induced by the oxidant pair ascorbate/Fe2+...