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Genetic toxicology evaluation of essential oil of Alpinia zerumbet and its chem...
Cavalcanti, Bruno C.; Ferreira, José R. O.; Cabral, Igor O.; Magalhães, Hemerson I. F.; Oliveira, Cecília C. de; Rodrigues, Felipe A. R.Essential oil (EO) of Alpinia zerumbet leaves, at non-toxic concentrations (50–300 l g/mL), did not induce genotoxicity in human leukocytes. However, at the highest concentration (500 l g/mL) tested caused a reduction in cell proliferation and viability, and an increase in DNA damage. Moreover, in vivo experi- ments showed that EO (400 mg/kg) did not exert mutagenicity on peripheral blood cells and bone mar- ro...
Date: 2013
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Origin: Oasisbr