This work was supported by Decit, SCTIE, Brazilian Ministry of Health, Conselho Nacional de Desenvolvimento Cient?fico - CNPq (440685/ 2016-8, 440856/2016-7 and 421598/2018-2), Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior - CAPES - (88887.130716/2016-00), European Union?s Horizon 2020 Research and Innovation Programme under ZIKAlliance Grant Agreement (734548), STARBIOS (709517), Funda??o de Ampa...
Made available in DSpace on 2021-06-25T11:48:11Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-01-01; Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG); Introduction: Several natural products exhibit promising antineoplastic activity against bladder cancer cells, including allyl isothiocyanate (AITC). However, the AITC irritates the mucous membranes and induces eczematous or vesicular sk...
Made available in DSpace on 2018-11-26T17:20:55Z (GMT). No. of bitstreams: 0 Previous issue date: 2017-03-01; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Universidade Federal de Ouro Preto (UFOP); Silibinin is a natural phenol found in the seeds of the milk ...
Silibinin is a natural phenol found in the seeds of the milk thistle plant. Recent data have shown its effectiveness for preventing/treating bladder tumours. Therefore, in this study we investigated the cytotoxic and toxicogenetic activity of silibinin in bladder cancer cells with different TP53 statuses. Two bladder urothelial carcinoma cell lines were used: RT4 (wild-type TP53 gene) and T24 (mutated TP53 gene...