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Explaining RANKL inhibition by OPG through quantum biochemistry computations an...

Sousa, Bruno Lopes de; Barroso Neto, Ito Liberato; Oliveira, Evanildo Ferreira; Fonseca, Emerson Alberto da; Lima Neto, Pedro de; Ladeira, Luiz Orlando

Osteoporosis is a degenerative disease associated with excessive bone resorption, a natural process performed by osteoclasts. In turn, osteoclast maturation is critically regulated by the receptor activator of nuclear factor kB ligand (RANKL), its signalling receptor (RANK), and its decoy receptor osteoprotegerin (OPG). The critical role of the protein triad, RANK–RANKL–OPG, in osteoclastogenesis has made their...

Date: 2019   |   Origin: Oasisbr
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